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• W2143225164 abstract "AbstractThree glycosyltransferases have been identified in mammals that can initiate core 2 protein O glycosylation. Core 2 O-glycans are abundant among glycoproteins but, to date, few functions for these structures have been identified. To investigate the biological roles of core 2 O-glycans, we produced and characterized mice deficient in one or more of the three known glycosyltransferases that generate core 2 O-glycans (C2GnT1, C2GnT2, and C2GnT3). A role for C2GnT1 in selectin ligand formation has been described. We now report that C2GnT2 deficiency impaired the mucosal barrier and increased susceptibility to colitis. C2GnT2 deficiency also reduced immunoglobulin abundance and resulted in the loss of all core 4 O-glycan biosynthetic activity. In contrast, the absence of C2GnT3 altered behavior linked to reduced thyroxine levels in circulation. Remarkably, elimination of all three C2GnTs was permissive of viability and fertility. Core 2 O-glycan structures were reduced among tissues from individual C2GnT deficiencies and completely absent from triply deficient mice. C2GnT deficiency also induced alterations in I-branching, core 1 O-glycan formation, and O mannosylation. Although the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a significant influence on O-glycan biosynthesis and is important in multiple physiological processes. ACKNOWLEDGMENTSWe thank David Ditto for technical expertise with the hematological assays and Margo Streets and Trang Tran for technical expertise with the behavior assays. Jeffery Long assisted with the statistical analysis of the behavioral data.This study was funded in part by a Mizutani Foundation for Glycoscience award (J.D.M.), a Veterans Affairs Merit Review Grant (S.B.H.), the University of California San Diego Digestive Disease Research Development Center (S.B.H), and National Institute of Health grants HL057345 (J.D.M.), HL78784 (J.D.M.), GMG2116 (J.D.M.), CA33000 (M.F.), and P01CA71932 (M.F. and J.D.M.). J.D.M. is supported by the Howard Hughes Medical Institute. This study was also funded in part by Biotechnology and Biological Sciences Research Council grant BBF0083091 (A.D.) and Public Health Service grant DK080506 (S.B.H.). M.N.I. is supported by University Science Malaysia, Ministry of Higher Education.We declare that we have no competing financial interests." @default.
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• W2143225164 date "2009-07-01" @default.
• W2143225164 modified "2023-10-02" @default.
• W2143225164 title "Glycosyltransferase Function in Core 2-Type Protein O Glycosylation" @default.
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• W2143225164 cites W1661646150 @default.
• W2143225164 cites W1855226200 @default.
• W2143225164 cites W1963757547 @default.
• W2143225164 cites W1966268162 @default.
• W2143225164 cites W1966697925 @default.
• W2143225164 cites W1967217097 @default.
• W2143225164 cites W1969718019 @default.
• W2143225164 cites W1977458124 @default.
• W2143225164 cites W1989506542 @default.
• W2143225164 cites W1991350273 @default.
• W2143225164 cites W1991401793 @default.
• W2143225164 cites W1994018335 @default.
• W2143225164 cites W2000537947 @default.
• W2143225164 cites W2003099086 @default.
• W2143225164 cites W2003694035 @default.
• W2143225164 cites W2006044324 @default.
• W2143225164 cites W2007731313 @default.
• W2143225164 cites W2009118884 @default.
• W2143225164 cites W2009256048 @default.
• W2143225164 cites W2017020122 @default.
• W2143225164 cites W2021820035 @default.
• W2143225164 cites W2023045668 @default.
• W2143225164 cites W2027856108 @default.
• W2143225164 cites W2029385033 @default.
• W2143225164 cites W2030180824 @default.
• W2143225164 cites W2037101701 @default.
• W2143225164 cites W2041711980 @default.
• W2143225164 cites W2043000199 @default.
• W2143225164 cites W2047595952 @default.
• W2143225164 cites W2047754708 @default.
• W2143225164 cites W2050153157 @default.
• W2143225164 cites W2051948190 @default.
• W2143225164 cites W2052330087 @default.
• W2143225164 cites W2059005097 @default.
• W2143225164 cites W2059731066 @default.
• W2143225164 cites W2066203385 @default.
• W2143225164 cites W2067580785 @default.
• W2143225164 cites W2073410778 @default.
• W2143225164 cites W2073500221 @default.
• W2143225164 cites W2075421288 @default.
• W2143225164 cites W2075932427 @default.
• W2143225164 cites W2077261345 @default.
• W2143225164 cites W2078571502 @default.
• W2143225164 cites W2078621117 @default.
• W2143225164 cites W2080380130 @default.
• W2143225164 cites W2086818231 @default.
• W2143225164 cites W2087308464 @default.
• W2143225164 cites W2089974771 @default.
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• W2143225164 cites W2158729939 @default.
• W2143225164 cites W2165022229 @default.
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• W2143225164 cites W2171721922 @default.
• W2143225164 cites W2172069761 @default.
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• W2143225164 doi "https://doi.org/10.1128/mcb.00204-09" @default.
• W2143225164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2698761" @default.
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• W2143225164 hasPublicationYear "2009" @default.
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