Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143228462> ?p ?o ?g. }
- W2143228462 endingPage "2255" @default.
- W2143228462 startingPage "2241" @default.
- W2143228462 abstract "Crystals of membrane proteins and protein complexes often diffract to low resolution owing to their intrinsic molecular flexibility, heterogeneity or the mosaic spread of micro-domains. At low resolution, the building and refinement of atomic models is a more challenging task. The deformable elastic network (DEN) refinement method developed previously has been instrumental in the determinion of several structures at low resolution. Here, DEN refinement is reviewed, recommendations for its optimal usage are provided and its limitations are discussed. Representative examples of the application of DEN refinement to challenging cases of refinement at low resolution are presented. These cases include soluble as well as membrane proteins determined at limiting resolutions ranging from 3 to 7 Å. Potential extensions of the DEN refinement technique and future perspectives for the interpretation of low-resolution crystal structures are also discussed." @default.
- W2143228462 created "2016-06-24" @default.
- W2143228462 creator A5010095324 @default.
- W2143228462 creator A5019080704 @default.
- W2143228462 creator A5019402916 @default.
- W2143228462 date "2014-08-29" @default.
- W2143228462 modified "2023-09-26" @default.
- W2143228462 title "Deformable elastic network refinement for low-resolution macromolecular crystallography" @default.
- W2143228462 cites W1548178570 @default.
- W2143228462 cites W1608052268 @default.
- W2143228462 cites W1969672293 @default.
- W2143228462 cites W1975914851 @default.
- W2143228462 cites W1978743770 @default.
- W2143228462 cites W1989628699 @default.
- W2143228462 cites W1992490978 @default.
- W2143228462 cites W1995017064 @default.
- W2143228462 cites W2001265759 @default.
- W2143228462 cites W2003079343 @default.
- W2143228462 cites W2007176314 @default.
- W2143228462 cites W2009110345 @default.
- W2143228462 cites W2013083986 @default.
- W2143228462 cites W2017393660 @default.
- W2143228462 cites W2017421343 @default.
- W2143228462 cites W2017789182 @default.
- W2143228462 cites W2020405262 @default.
- W2143228462 cites W2020601776 @default.
- W2143228462 cites W2021419438 @default.
- W2143228462 cites W2032565934 @default.
- W2143228462 cites W2035667407 @default.
- W2143228462 cites W2041654633 @default.
- W2143228462 cites W2046141572 @default.
- W2143228462 cites W2047173579 @default.
- W2143228462 cites W2056331547 @default.
- W2143228462 cites W2065283382 @default.
- W2143228462 cites W2067911054 @default.
- W2143228462 cites W2069777230 @default.
- W2143228462 cites W2084584451 @default.
- W2143228462 cites W2092220359 @default.
- W2143228462 cites W2092875818 @default.
- W2143228462 cites W2095593044 @default.
- W2143228462 cites W2096025413 @default.
- W2143228462 cites W2104477830 @default.
- W2143228462 cites W2115813898 @default.
- W2143228462 cites W2116275717 @default.
- W2143228462 cites W2116960458 @default.
- W2143228462 cites W2117323215 @default.
- W2143228462 cites W2118755520 @default.
- W2143228462 cites W2124026197 @default.
- W2143228462 cites W2125304058 @default.
- W2143228462 cites W2127130852 @default.
- W2143228462 cites W2132351632 @default.
- W2143228462 cites W2144081223 @default.
- W2143228462 cites W2150008490 @default.
- W2143228462 cites W2152301430 @default.
- W2143228462 cites W2152997134 @default.
- W2143228462 cites W2154197653 @default.
- W2143228462 cites W2154714625 @default.
- W2143228462 cites W2159211495 @default.
- W2143228462 cites W2159407190 @default.
- W2143228462 cites W2160809534 @default.
- W2143228462 cites W2161962235 @default.
- W2143228462 cites W2162166182 @default.
- W2143228462 cites W2163341755 @default.
- W2143228462 cites W2164489181 @default.
- W2143228462 cites W2180229411 @default.
- W2143228462 doi "https://doi.org/10.1107/s1399004714016496" @default.
- W2143228462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4157441" @default.
- W2143228462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25195739" @default.
- W2143228462 hasPublicationYear "2014" @default.
- W2143228462 type Work @default.
- W2143228462 sameAs 2143228462 @default.
- W2143228462 citedByCount "29" @default.
- W2143228462 countsByYear W21432284622015 @default.
- W2143228462 countsByYear W21432284622016 @default.
- W2143228462 countsByYear W21432284622017 @default.
- W2143228462 countsByYear W21432284622018 @default.
- W2143228462 countsByYear W21432284622019 @default.
- W2143228462 countsByYear W21432284622020 @default.
- W2143228462 countsByYear W21432284622021 @default.
- W2143228462 countsByYear W21432284622022 @default.
- W2143228462 countsByYear W21432284622023 @default.
- W2143228462 crossrefType "journal-article" @default.
- W2143228462 hasAuthorship W2143228462A5010095324 @default.
- W2143228462 hasAuthorship W2143228462A5019080704 @default.
- W2143228462 hasAuthorship W2143228462A5019402916 @default.
- W2143228462 hasBestOaLocation W21432284621 @default.
- W2143228462 hasConcept C105795698 @default.
- W2143228462 hasConcept C11413529 @default.
- W2143228462 hasConcept C127313418 @default.
- W2143228462 hasConcept C127413603 @default.
- W2143228462 hasConcept C138268822 @default.
- W2143228462 hasConcept C154945302 @default.
- W2143228462 hasConcept C185592680 @default.
- W2143228462 hasConcept C188198153 @default.
- W2143228462 hasConcept C199360897 @default.
- W2143228462 hasConcept C2780598303 @default.
- W2143228462 hasConcept C3019883945 @default.
- W2143228462 hasConcept C3020199158 @default.