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• W2143251483 startingPage "1670" @default.
• W2143251483 abstract "CD11a/CD18 (beta2)-integrins are expressed on leukocytes and are involved in cell adhesion and signaling. Despite extensive studies the signaling pathways and molecular mechanisms involved in integrin regulation in T cells remain not completely understood. We have now studied the involvement of the tyrosine kinase Lck in the regulation of CD11a/CD18 function in Jurkat T cells. Using the Src-family kinase inhibitor PP2, we found that CD3 ligation-induced adhesion to ICAM-1 was inhibited by PP2 at the same concentration required for complete inhibition of the MAP kinase pathway, implicating a role for Lck in integrin activation. We therefore used the Lck-deficient Jurkat cell line JCaM1.6 to further examine the involvement of Lck in integrin regulation. Interestingly, JCaM1.6 cells showed dramatically reduced levels of both CD3- and phorbol ester-induced adhesion to coated ICAM-1 as compared to normal Jurkat cells. By using flow cytometry and cell surface labeling, it was found that the surface expression of the CD11a/CD18-integrins was significantly lower in Lck-deficient T cells as compared to normal Jurkat cells. CD18 was expressed as a mature and an immaturely glycosylated form in Jurkat T cell lines, and predominantly the immature form, not associated with CD11a, was found in Lck-deficient cells. Retransfection of human Lck in JCaM1.6 cells restored adhesion. Thus, Lck is involved in regulating CD11a/CD18-integrins in T cells." @default.
• W2143251483 created "2016-06-24" @default.
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• W2143251483 date "2002-06-01" @default.
• W2143251483 modified "2023-09-25" @default.
• W2143251483 title "Lck tyrosine kinase is important for activation of the CD11a/CD18-integrins in human T lymphocytes" @default.
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• W2143251483 doi "https://doi.org/10.1002/1521-4141(200206)32:6<1670::aid-immu1670>3.0.co;2-m" @default.
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• W2143251483 hasPublicationYear "2002" @default.
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