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• W2143259378 abstract "We have previously identified a new centrosomal protein, centrosomal protein 4.1-associated protein (CPAP), which is associated with the γ-tubulin complex. Here, we report that CPAP carries a novel microtubule-destabilizing motif that not only inhibits microtubule nucleation from the centrosome but also depolymerizes taxol-stabilized microtubules. Deletion mapping and functional analyses have defined a 112-residue CPAP that is necessary and sufficient for microtubule destabilization. This 112-residue CPAP directly recognizes the plus end of a microtubule and inhibits microtubule nucleation from the centrosome. Biochemical and functional analyses revealed that this 112-residue CPAP also binds to tubulin dimers, resulting in the destabilization of microtubules. Using the tetracycline-controlled system (tet-off), we observed that overexpression of this 112-residue CPAP inhibits cell proliferation and induces apoptosis after G2/M arrest. The possible mechanisms of how this 112-residue motif in CPAP that inhibits microtubule nucleation from the centrosome and disassembles preformed microtubules are discussed." @default.
• W2143259378 created "2016-06-24" @default.
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• W2143259378 date "2004-06-01" @default.
• W2143259378 modified "2023-10-17" @default.
• W2143259378 title "Identification of a Novel Microtubule-destabilizing Motif in CPAP That Binds to Tubulin Heterodimers and Inhibits Microtubule Assembly" @default.
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• W2143259378 doi "https://doi.org/10.1091/mbc.e04-02-0121" @default.
• W2143259378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/420094" @default.
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