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• W2143263174 endingPage "R437" @default.
• W2143263174 startingPage "R421" @default.
• W2143263174 abstract "Cardiac activity of the turtle ( Trachemys scripta) is greatly depressed with cold acclimation and anoxia. We examined what electrophysiological modifications accompany and perhaps facilitate this depression of cardiac activity. Turtles were first acclimated to 21°C or 5°C and held under either normoxic or anoxic (6 h at 21°C; 14 days at 5°C) conditions. We then measured cardiac action potentials (APs) using spontaneously contracting whole heart preparations and whole cell current densities of sarcolemmal ion channels using isolated ventricular myocytes under appropriate normoxic and anoxic conditions. Compared with 21°C-acclimated turtles, 5°C-acclimated turtles exhibited a less negative resting membrane potential (by 18–29 mV), a 4.7- to 6.8-fold slower AP upstroke rate, and a 4.2- to 4.9-fold greater AP duration. Correspondingly, peak densities of ventricular voltage-gated Na + ( I Na ) and L-type Ca 2+ currents and inward slope conductances of inward rectifier K + ( I K1 ) channel current were ∼1/7th (Q 10 = 3.4), 1/13th (Q 10 = 5.0), and one-half (Q 10 = 1.4) of those of 21°C-acclimated ventricular myocytes, respectively. With anoxia at 21°C, peak I Na density doubled and ventricular AP duration increased by 47%, a change proportional to the reported ∼30% reduction of intrinsic heart rate. In contrast, with anoxia at 5°C, ventricular AP characteristics were unaffected; of the ion currents investigated, only the inward conductance via I K1 changed significantly (reduced by 46%). The present findings indicate that cold temperature, more so than prolonged anoxia, results in substantial modifications of cardiac APs and reduction of ventricular ion current densities. These changes likely prepare cardiac muscle for winter anoxia conditions." @default.
• W2143263174 created "2016-06-24" @default.
• W2143263174 creator A5015912531 @default.
• W2143263174 creator A5018279192 @default.
• W2143263174 creator A5062989015 @default.
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• W2143263174 date "2007-07-01" @default.
• W2143263174 modified "2023-09-26" @default.
• W2143263174 title "Effect of temperature and prolonged anoxia exposure on electrophysiological properties of the turtle (<i>Trachemys scripta</i>) heart" @default.
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• W2143263174 doi "https://doi.org/10.1152/ajpregu.00096.2007" @default.
• W2143263174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17442785" @default.
• W2143263174 hasPublicationYear "2007" @default.
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