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• W2143282938 abstract "Purpose: To investigate the neuroprotective and immunomodulatory effects of mesenchymal stem cells (MSCs) engineered to secrete CX3CL1 on the light-injured retinal structure and function.Methods: Normal MSCs and CX3CL1-expressing MSCs (CX3CL1-MSCs) were transplanted into the subretinal space of light-injured rats. By ERG and TUNEL methods, their rescue effect of the host retina was compared with untreated light-injured and vehicle-injected rats. Activated microglia in the retina were stained by ED-1 antibody, and Western blot was performed to quantify cytokines secreted by the retina post-transplantation.Results: ERG analysis showed better function in CX3CL1-MSC-injected group than other groups at 21 days after transplantation (p < 0.05). CX3CL1-MSCs inhibited apoptosis of the retinal cells and microglial activation. Neurotrophic factors expression in host retina that received CX3CL1-MSCs was stronger than in the retina that received normal MSCs. Conversely, the expression of proinflammatory factors was downregulated.Conclusions: CX3CL1-MSCs subretinal transplantation may enhance protective effect against light-induced retinal degeneration." @default.
• W2143282938 created "2016-06-24" @default.
• W2143282938 creator A5040983782 @default.
• W2143282938 creator A5058417243 @default.
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• W2143282938 date "2013-05-29" @default.
• W2143282938 modified "2023-10-18" @default.
• W2143282938 title "Transplantation of CX3CL1-expressing Mesenchymal Stem Cells Provides Neuroprotective and Immunomodulatory Effects in a Rat Model of Retinal Degeneration" @default.
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• W2143282938 doi "https://doi.org/10.3109/09273948.2013.791925" @default.
• W2143282938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23718544" @default.
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