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• W2143285417 abstract "This editorial refers to an article by D.J. Hausenloy et al .[25][1] published in Cardiovascular Research in 2002. It is accompanied by a retrospective editorial by the authors of that original article, D.J. Hausenloy et al ., pp. 160–164, this issue, as part of this Spotlight on Landmark Papers in Cardiovascular Research . Since its first description 25 years ago,1 ischaemic preconditioning has become one of the most studied protective interventions in the cardiovascular field, in part due to its universality (it is effective in all animal species tested, including humans, and in different organs) and reproducibility (it has only a weak dependence on the ischaemic protocol applied before sustained ischaemia or on the duration and severity of the ischaemic insult). The identification of the involved signalling pathways and end-effectors was expected to have important therapeutic implications. However, despite the enormous amount of experimental data, our understanding of the cellular mechanisms responsible for preconditioning protection remains incomplete and at some points controversial. The reason for this failure is demonstrated by the large number of publications describing different molecular pathways involved in protection, some of them acting in parallel or being redundant or dispensable, whereas others appear to be additive or to operate in series, making it very difficult to integrate them into a comprehensive survival pathway. No less important was the lack of understanding of the ultimate mechanisms (end-effectors) by which these signalling pathways reduce cell death. End-effectors of preconditioning have to be molecules downstream the signalling pathway directly involved in cell death. They have the greatest therapeutic interest for obvious reasons; however, their identification has proved not to be a trivial task, and multiple candidates … [1]: #ref-25" @default.
• W2143285417 created "2016-06-24" @default.
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• W2143285417 date "2012-07-31" @default.
• W2143285417 modified "2023-10-17" @default.
• W2143285417 title "Ischaemic preconditioning and mitochondrial permeability transition: a long-lasting relationship: EXPERT'S PERSPECTIVE" @default.
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• W2143285417 doi "https://doi.org/10.1093/cvr/cvs177" @default.
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