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- W2143286912 abstract "To assess the relationship between umbilical artery acid-base status and major neurodevelopmental disability at age 6 years among very preterm births (VPTB). Secondary analysis of a prospective cohort of 457 VPTBs between 23 and 32 weeks′ from 1996-2001. Arterial cord gas parameters <10th %tile for pH (<7.1), base excess (< −8.6 mEq/L), bicarbonate (<21 mEq/L), PO2 (<29 mm Hg) and > 90th percentile for PCO2 (>77 mm Hg) were considered abnormal. Neurodevelopmental disability was defined as IQ <70, or the composite of IQ<70, cerebral palsy, blindness, deafness or other major deficits (abnormal balance, impaired coordination, dystonia and seizure disorder). Logistic regression was used to adjust for race and parental IQ and (in additional analyses) for gestational age (GA). 261 of 375 survivors with mean GA of 28.8 weeks were evaluated at mean age of 6.8 years. In unadjusted analyses, GA (inversely) and abnormal pH, base excess and pC02, but not bicarbonate or pO2, were associated with long-term disability. Multivariable analyses with and without adjustment for GA (as a continuous variable) are presented in the table. Not shown, each 1 week increase in GA, was associated with a 25-28% significant decrease in adjusted risks of IQ<70 and composite major disability. Children with cord gas abnormalities had higher rates of disability within sub-groups of earlier and later GA.Tabled 1 The risk of long-term major neurodevelopmental disability associated with abnormal cord pH and base excess remains considerably increased (over 2-fold) after accounting for the strong association with GA. However, a much larger cohort would be needed to conclusively assert the suggested association between cord gas abnormalities and long-term disability." @default.
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- W2143286912 date "2008-12-01" @default.
- W2143286912 modified "2023-09-26" @default.
- W2143286912 title "317: Umbilical cord gases and neuro-developmental disability in very preterm births" @default.
- W2143286912 doi "https://doi.org/10.1016/j.ajog.2008.09.345" @default.
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