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- W2143295719 abstract "Endometriosis is commonly seen in infertility patients. Its effect on specific fertility parameters such as embryo quality and endometrial receptivity is controversial. In order to examine the effects of endometriosis on embryo quality, we examined in vitro fertilization (IVF) data in patients before and after surgical treatment for endometriosis. Retrospective cohort. We identified patients who had IVF before and after surgical treatment of endometriosis. Surgery involved complete resection of all endometriosis lesions and removal of endometriomas by laparoscopy. Data collected included patient demographics, stimulation protocol, oocytes retrieved, fertilization type, endometrial thickness, quantity and quality of embryos available, and pregnancy outcomes. If a patient had multiple cycles before surgery, only cycles with similar protocols and closest in time to surgery were included. 26 patients were identified. All patients had failed to conceive with the first IVF cycle. FSH levels (6.9 and 7.0 mIU/mL), days of stimulation (11 and 10), and amount of gonadotropins used (4875 vs. 5025 IU) were similar before and after surgery. The average age at the time of surgery was 35.9 years. The interval between surgery and second IVF cycle was 254 days. No hydrosalpinxes were found at time of surgery. There was no difference in the number or quality of embryos before and after surgery as shown in Table 1. The live birth rate per IVF cycle after surgical treatment of endometriosis was 46% (12/26). The age of patients that conceived was significantly lower, 34.2 vs. 36.8 years, P=0.02. Pregnancy rate was 53% for patients with Stage I-II endometriosis and 36% for those with Stage III–IV endometriosis, this difference did not reach statistical significance. TableIVF cycle before surgeryIVF cycle after surgeryAge35.436.6Endometrial Thickness in mm10.310.2Average Number of Oocytes Retrieved1210Average Number of Embryos6.45.8Average Number of Good Quality Embryos∗6 cell or higher and grade I or II. on Day 34.03.6Average Number of 8 cell Embryos on Day 33.02.6Average Number of Embryos Transferred2.73.2∗ 6 cell or higher and grade I or II. Open table in a new tab Surgical treatment of endometriosis had no impact on embryo quality in patients who had failed IVF. Further studies are needed to better understand how endometriosis and its treatment affect the success of IVF." @default.
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- W2143295719 date "2007-09-01" @default.
- W2143295719 modified "2023-09-30" @default.
- W2143295719 title "Surgical treatment of endometriosis and embryo quality" @default.
- W2143295719 doi "https://doi.org/10.1016/j.fertnstert.2007.07.732" @default.
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