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• W2143315188 abstract "Organophosphorus hydrolase (OPH) is capable of hydrolyzing a wide variety of organophosphorus pesticides and chemical warfare agents. However, the hydrolytic activity of OPH against the warfare agent VX is less than 0.1% relative to its activity against parathion and paraoxon. Based on the crystal structure of OPH and the similarities it shares with acetylcholinesterase, eight OPH mutants were constructed with the goal of increasing OPH activity toward VX. The activities of crude extracts from these mutants were measured using VX, demeton-S methyl, diisopropylfluoro-phosphate, ethyl parathion, paraoxon, and EPN as substrates. One mutant (L136Y) displayed a 33% increase in the relative VX hydrolysis rate compared to wild type enzyme. The other seven mutations resulted in 55–76% decreases in the relative rates of VX hydrolysis. There was no apparent relationship between the hydrolysis rates of VX and the rates of the other organophosphorus compounds tested." @default.
• W2143315188 created "2016-06-24" @default.
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• W2143315188 date "2000-12-01" @default.
• W2143315188 modified "2023-09-27" @default.
• W2143315188 title "Mutagenesis of Organophosphorus Hydrolase to Enhance Hydrolysis of the Nerve Agent VX" @default.
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• W2143315188 doi "https://doi.org/10.1006/bbrc.2000.4004" @default.
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