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• W2143320199 abstract "Objective. To define the influence of the T cell receptor (TCR) and the lpr autoimmune gene on the induction and progression of superantigen-induced arthritis in V β8 transgenic MRL-lpr/lpr mice. Methods. The time to onset and the extent of synovial hyperplasia after the induction of arthritis by intraarticular injection of staphylococcal enterotoxin B (SEB) were compared in mice having T cells that bear the V β8 transgene alone (V β8 TCR transgenic MRL-+/+), the lpr gene without the V β8 gene (nontransgenic MRL-lpr/lpr), both the V β8 gene and the lpr gene (V β8 transgenic MRL-lpr/lpr), or neither gene (nontransgenic MRL-+/+). Synovial hyperplasia was compared in SEB-injected V β8 transgenic MRL-lpr/lpr mice after treatment with cyclosporin A (CSA), anti-V β8 and anti-CD4 monoclonal antibodies, and in V β8 transgenic MRL-lpr/lpr mice after injection of a non—V β8-reactive superantigen, staphylococcal enterotoxin A (SEA). Results. At day 30, increased synovial cells were observed in all SEB-treated mice, but the increase was greatest in the V β8 transgenic MRL-lpr/lpr mice. T cell involvement was indicated by the inability of either heat-denatured SEB or SEA to induce severe arthritis, the reduction in the severity of the arthritis on systemic treatment with CSA or anti-V β8, and the correlation of synovial hyperplasia with in vitro SEB reactivity of T cells. Conclusion. These observations suggest that super-antigens can induce chronic arthritis and that the induction and progression of the arthritis requires an underlying T cell defect in anergy induction in addition to exposure to the superantigen." @default.
• W2143320199 created "2016-06-24" @default.
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• W2143320199 date "1994-01-01" @default.
• W2143320199 modified "2023-09-24" @default.
• W2143320199 title "T Cell Influence on Superantigen-Induced Arthritis in MRL-lpr/lpr Mice" @default.
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• W2143320199 doi "https://doi.org/10.1002/art.1780370117" @default.
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