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- W2143338670 abstract "While searching for novel nonsteroidal inhibitors of human and rat prostatic 5alpha-reductases, we found a new series of indoline and aniline derivatives that showed potent inhibitory activities for both enzymes. Among them, 3-chloro-4-¿[1-(4-phenoxybenzyl)indolin-5-yl]oxylbenzoic acid (2e, YM-36117) showed a more potent inhibitory activity for the human enzyme than ONO-3805 with an IC50 value of 5.3 nM and a reduced rat prostatic dihydrotestosterone (DHT) concentration by oral administration. The synthesis and the structure-activity relationships of these indoline and aniline derivatives are presented." @default.
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- W2143338670 date "2000-01-01" @default.
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- W2143338670 title "A Novel Class of Inhibitors for Human and Rat Steroid 5.ALPHA.-Reductases: Synthesis and Biological Evaluation of Indoline and Aniline Derivatives. III." @default.
- W2143338670 doi "https://doi.org/10.1248/cpb.48.1689" @default.
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