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• W2143340848 abstract "Developing binocular projections to the Xenopus tectum require visual input in order to establish matching topographic maps. In dark-reared Xenopus, the ipsilateral eye's map, relayed via the retino-tecto-isthmotectal pathway, fails initially to acquire normal rostrocaudal order. Moreover, with extended time in the dark, the ipsilateral map becomes progressively less well organized. This phenomenon showed that without binocular cues, the isthmotectal axons are unable to locate proper sites for their terminal zones but left open the issue of whether the axons are able to establish arbors of normal dimensions and/or to sustain normal numbers of branches. In order to test whether dark-rearing modifies isthmotectal axon branching, we have used horseradish peroxidase to examine axons of Xenopus after dark-rearing for periods from 3 to 298 weeks. The results demonstrate that these axons never acquire more than about half the normal numbers of terminals. Surprisingly, however, the dark-reared axons' terminal zones are normal in mediolateral and rostrocaudal extent despite the lack of binocular cues that normally could constrain arbor size by inducing pruning of branches in regions with mismatched visual inputs. The effects of dark-rearing are reversible. After a return to normal lighting conditions, the recovery process begins quickly, with a significant increase in branch numbers within 4 weeks. The terminal zone remains of normal dimensions. These results support the hypothesis that correlated binocular visual input is essential for the maintenance of normal numbers of isthmotectal branches but that normal termination zone size can be established in the absence of visual cues." @default.
• W2143340848 created "2016-06-24" @default.
• W2143340848 creator A5039729176 @default.
• W2143340848 date "2008-01-01" @default.
• W2143340848 modified "2023-09-25" @default.
• W2143340848 title "Isthmotectal axons maintain normal arbor size but fail to support normal branch numbers in dark-rearedXenopus laevis" @default.
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• W2143340848 doi "https://doi.org/10.1002/cne.21633" @default.
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