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- W2143341607 abstract "Glial cells differentiate from the neuroepithelium. In flies, gliogenesis depends on the expression of glial cell deficient/glial cell missing (glide/gcm). The phenotype of glide/gcm loss- and gain-of-function mutations suggested that gliogenesis occurs in cells that, by default, would differentiate into neurons. Here we show that glide/gcm is able to induce cells even from a distinct germ layer, the mesoderm, to activate the glial developmental program, which demonstrates that gliogenesis does not require a ground neural state. These findings challenge the common view on the establishment of cell diversity in the nervous system. Strikingly, ectopic glide/gcm overrides positional information by repressing the endogenous developmental program. These findings also indicate that glial differentiation tightly depends on glide/gcm transcriptional regulation. It is likely that glide/gcm homologs act similarly during vertebrate gliogenesis." @default.
- W2143341607 created "2016-06-24" @default.
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- W2143341607 date "1998-08-15" @default.
- W2143341607 modified "2023-09-26" @default.
- W2143341607 title "Glial differentiation does not require a neural ground state" @default.
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- W2143341607 doi "https://doi.org/10.1242/dev.125.16.3189" @default.
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