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• W2143344522 abstract "Fibulin-3, originally identified in senescent and Werner syndrome fibroblasts, has been implicated in cell morphology, growth, adhesion and motility. Fibulin-3 exhibits both antitumor and oncogenic activities towards human cancers; however, the role of Fibulin-3 in hepatocellular carcinoma (HCC) remains elusive. In this study, we showed that both the mRNA and protein levels of Fibulin-3 were remarkably downregulated in HCC cell lines and fresh tissues. Immunohistochemical data revealed that Fibulin-3 was decreased in tumorous tissues in 67.1% (171/255) of cases compared to the corresponding adjacent nontumorous tissues. The results of statistical analysis indicated that low Fibulin-3 expression, defined by the receiver operating characteristic curve (ROC), was significantly associated with tumor differentiation (P=0.008), clinical stage (P=0.014) and serum AFP levels (P<0.01). Furthermore, Kaplan-Meier and multivariate analysis suggested that Fibulin-3 is an independent negative prognostic indicator for both overall (P<0.001) and recurrence-free (P=0.036) survival. In addition, an in vitro study demonstrated that knockdown of Fibulin-3 by siRNA markedly increased cell viability and promoted cell invasion in HCC cells. Collectively, our data suggest that Fibulin-3 exhibits antitumor effects towards HCC and serves as a biomarker of unfavorable prognosis for this deadly disease." @default.
• W2143344522 created "2016-06-24" @default.
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• W2143344522 date "2013-08-01" @default.
• W2143344522 modified "2023-09-27" @default.
• W2143344522 title "Decrease of Fibulin-3 in Hepatocellular Carcinoma Indicates Poor Prognosis" @default.
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• W2143344522 doi "https://doi.org/10.1371/journal.pone.0070511" @default.
• W2143344522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731361" @default.
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• W2143344522 hasPublicationYear "2013" @default.
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