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• W2143370650 abstract "Asymmetric body axis formation is central to metazoan development. Dictyostelium establishes an anterior/posterior axis utilizing seven-transmembrane cAMP morphogen receptors (CARs) and GSK3-mediated signal transductions that has a parallel with metazoan Wnt/Frizzled-GSK3 pathways. In Dictyostelium, GSK3 promotes posterior cell patterning but inhibits anterior cell differentiation. Tyrosine kinase ZAK1 mediates GSK3 activation. We now show that CAR4 regulates a tyrosine phosphatase that inhibits GSK3 activity. We have also identified essential phosphotyrosines in GSK3, confirmed their role in activated/deactivated regulation and cell fate decisions, and relate them to the predicted 3D structure of GSK3β. CARs differentially regulate GSK3 activity by selectively activating a tyrosine phosphatase or kinase for pattern formation. The findings may provide a comparative understanding of CAR-GSK3 and Wnt/Frizzled-GSK3 pathways." @default.
• W2143370650 created "2016-06-24" @default.
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• W2143370650 date "2002-10-01" @default.
• W2143370650 modified "2023-10-17" @default.
• W2143370650 title "Receptor-Dependent and Tyrosine Phosphatase-Mediated Inhibition of GSK3 Regulates Cell Fate Choice" @default.
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• W2143370650 doi "https://doi.org/10.1016/s1534-5807(02)00269-1" @default.
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