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• W2143384720 endingPage "142" @default.
• W2143384720 startingPage "131" @default.
• W2143384720 abstract "ABSTRACT- Alterations in nervous system functioning following acute and chronic ethanol exposure have been studied in a great number of experimental investigations. Results from many of these investigations can be difficult to interpret, particularly since a variety of techniques and exposure models are employed. This review emphasizes those studies which, in the opinion of the author, fit into a pattern where results from studying one function of the nervous system is in accordance with results from studying another. Thus, the fluidizing effect of ethanol on the neuronal membrane - an effect which ethanol shares with anaesthetics - leads to a change in protein function which in turn affects ion transport such as Na+ and Ca++ across the membrane due to changes in the ion channels. Cation influx is probably directly coupled to neurotransmitter release which is in agreement with the finding that ethanol exposure results in inhibition of Na+ and Ca++ current as well as acetylcholine release. The sensitation of the dopaminergic system after ethanol exposure may also be related to the changes in cation flux, and the changes in this system probably play a crucial rôle in the development of tolerance and withdrawal symptoms. Other aspects such as impairment of protein synthesis, altered GABA function of impairment of neuron excitability and conduction are more difficult to place in proper perspective. The rôle of acetaldehyde in acute as well as chronic ethanol intoxication also remains a controversy. These may, however, be secondary phenomena to primary changes in different part of the nervous system not necessarily important in the clinical situation. Behavioural and anatomical studies particularly from recent years have shown that experimental animals develop memory disturbances following chronic exposure even when kept on sufficient diet. These findings argue strongly for a direct toxic effect of ethanol, and are furthermore compatible with behavioural changes in chronic alcoholics, dominated by memory impairment. Since it has been argued that the cholinergic system plays a significant rôle for memory function, a possible explanation for some of the psychological and anatomical deficits caused by ethanol is thus the changes in the function of the cholinergic system particularly in the hippocampal regions." @default.
• W2143384720 created "2016-06-24" @default.
• W2143384720 creator A5076510248 @default.
• W2143384720 date "1983-03-01" @default.
• W2143384720 modified "2023-09-24" @default.
• W2143384720 title "The neurotoxicity of ethanol" @default.
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• W2143384720 cites W1967139082 @default.
• W2143384720 cites W1974196325 @default.
• W2143384720 cites W1975529368 @default.
• W2143384720 cites W1977071769 @default.
• W2143384720 cites W1978277366 @default.
• W2143384720 cites W1980284798 @default.
• W2143384720 cites W1981084312 @default.
• W2143384720 cites W1981087780 @default.
• W2143384720 cites W1985141819 @default.
• W2143384720 cites W1985186507 @default.
• W2143384720 cites W1985740375 @default.
• W2143384720 cites W1986354246 @default.
• W2143384720 cites W1987387385 @default.
• W2143384720 cites W1988980509 @default.
• W2143384720 cites W1989677576 @default.
• W2143384720 cites W1992266010 @default.
• W2143384720 cites W1992333764 @default.
• W2143384720 cites W1996195235 @default.
• W2143384720 cites W1997374895 @default.
• W2143384720 cites W1998486206 @default.
• W2143384720 cites W1999233505 @default.
• W2143384720 cites W2003225652 @default.
• W2143384720 cites W2004445728 @default.
• W2143384720 cites W2006684969 @default.
• W2143384720 cites W2010261192 @default.
• W2143384720 cites W2010762539 @default.
• W2143384720 cites W2018162918 @default.
• W2143384720 cites W2022651316 @default.
• W2143384720 cites W2024563504 @default.
• W2143384720 cites W2032191724 @default.
• W2143384720 cites W2032705173 @default.
• W2143384720 cites W2032770590 @default.
• W2143384720 cites W2032788212 @default.
• W2143384720 cites W2037387800 @default.
• W2143384720 cites W2038656329 @default.
• W2143384720 cites W2041655276 @default.
• W2143384720 cites W2046338368 @default.
• W2143384720 cites W2055375934 @default.
• W2143384720 cites W2059584607 @default.
• W2143384720 cites W2060177127 @default.
• W2143384720 cites W2060569665 @default.
• W2143384720 cites W2061569541 @default.
• W2143384720 cites W2062881692 @default.
• W2143384720 cites W2069398716 @default.
• W2143384720 cites W2071538403 @default.
• W2143384720 cites W2076060576 @default.
• W2143384720 cites W2076501023 @default.
• W2143384720 cites W207782640 @default.
• W2143384720 cites W2078877036 @default.
• W2143384720 cites W2080251500 @default.
• W2143384720 cites W2084726236 @default.
• W2143384720 cites W2085119136 @default.
• W2143384720 cites W2085362834 @default.
• W2143384720 cites W2086730201 @default.
• W2143384720 cites W2088835609 @default.
• W2143384720 cites W2090724259 @default.
• W2143384720 cites W2091334041 @default.
• W2143384720 cites W2107303243 @default.
• W2143384720 cites W2112878459 @default.
• W2143384720 cites W2117614741 @default.
• W2143384720 cites W2118563686 @default.
• W2143384720 cites W2128805948 @default.
• W2143384720 cites W2147207709 @default.
• W2143384720 cites W2148249115 @default.
• W2143384720 cites W2154701791 @default.
• W2143384720 cites W2167223720 @default.
• W2143384720 cites W2202837700 @default.
• W2143384720 cites W2396973786 @default.
• W2143384720 cites W2401059362 @default.
• W2143384720 cites W2404426883 @default.
• W2143384720 cites W2416367425 @default.
• W2143384720 cites W2419278520 @default.
• W2143384720 cites W2501503941 @default.
• W2143384720 cites W2893287458 @default.
• W2143384720 cites W4234187574 @default.
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• W2143384720 doi "https://doi.org/10.1111/j.1600-0404.1983.tb04556.x" @default.
• W2143384720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6135290" @default.
• W2143384720 hasPublicationYear "1983" @default.
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