FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143390187> ?p ?o ?g. }

• W2143390187 endingPage "965" @default.
• W2143390187 startingPage "958" @default.
• W2143390187 abstract "Objectives. Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integrity. This study assesses the effects of a RetA + OSM combination on cartilage catabolism. Methods. Animal and human cartilage samples were used to assess the ability of RetA + OSM to promote the release of collagen and proteoglycan fragments, which was determined by measuring glycosaminoglycan and hydroxyproline, respectively. Total collagenolytic and tissue inhibitor of metalloproteinases (TIMP) inhibitory activities were determined by bioassay, whilst gene expression of matrix metalloproteinases (MMPs) and TIMP-1 were determined by northern blotting. Immunohistochemistry was used to assess the presence of MMP-1 and -13 in resorbing cartilage explants. Results. Both agents alone induced proteoglycan release from bovine cartilage, whilst RetA-induced collagen release was variable. Reproducible and synergistic collagenolysis was observed with RetA + OSM, which appeared to be due to MMP-13. Similar collagen release was observed from porcine cartilage. Conversely, no collagen release was seen with human articular cartilage. In primary human chondrocytes, RetA + OSM failed to induce MMP-1 or -13 but caused a significant increase in TIMP-1 expression. Conclusions. These novel observations show that the combination of RetA + OSM has profound effects on cartilage matrix turnover, but these effects are species-specific. A better understanding of the mechanism by which this combination differentially regulates MMP and TIMP expression in human chondrocytes could provide valuable insight into new therapeutic strategies aimed at the prevention of cartilage destruction." @default.
• W2143390187 created "2016-06-24" @default.
• W2143390187 creator A5009800567 @default.
• W2143390187 creator A5041932326 @default.
• W2143390187 creator A5051975326 @default.
• W2143390187 creator A5057660100 @default.
• W2143390187 creator A5059164931 @default.
• W2143390187 date "2006-02-08" @default.
• W2143390187 modified "2023-09-25" @default.
• W2143390187 title "Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes" @default.
• W2143390187 cites W1593295279 @default.
• W2143390187 cites W1968356908 @default.
• W2143390187 cites W1969179229 @default.
• W2143390187 cites W1975523013 @default.
• W2143390187 cites W1983729225 @default.
• W2143390187 cites W1989949914 @default.
• W2143390187 cites W1993087594 @default.
• W2143390187 cites W1995304518 @default.
• W2143390187 cites W1997717120 @default.
• W2143390187 cites W2002807336 @default.
• W2143390187 cites W2008236596 @default.
• W2143390187 cites W2020731606 @default.
• W2143390187 cites W2032255522 @default.
• W2143390187 cites W2032337876 @default.
• W2143390187 cites W2036824008 @default.
• W2143390187 cites W2043068076 @default.
• W2143390187 cites W2046331668 @default.
• W2143390187 cites W2047836730 @default.
• W2143390187 cites W2056540680 @default.
• W2143390187 cites W2065014069 @default.
• W2143390187 cites W2067581223 @default.
• W2143390187 cites W2073595043 @default.
• W2143390187 cites W2075638066 @default.
• W2143390187 cites W2077007714 @default.
• W2143390187 cites W2078180135 @default.
• W2143390187 cites W2084168776 @default.
• W2143390187 cites W2086840459 @default.
• W2143390187 cites W2087193732 @default.
• W2143390187 cites W2088930264 @default.
• W2143390187 cites W2090671320 @default.
• W2143390187 cites W2094990443 @default.
• W2143390187 cites W2098382287 @default.
• W2143390187 cites W2103691455 @default.
• W2143390187 cites W2106189080 @default.
• W2143390187 cites W2108913064 @default.
• W2143390187 cites W2118090969 @default.
• W2143390187 cites W2121385382 @default.
• W2143390187 cites W2128049766 @default.
• W2143390187 cites W2133197725 @default.
• W2143390187 cites W2138960046 @default.
• W2143390187 cites W2152217106 @default.
• W2143390187 cites W2152266604 @default.
• W2143390187 cites W2154401382 @default.
• W2143390187 cites W2162379603 @default.
• W2143390187 cites W2165394244 @default.
• W2143390187 cites W2170167935 @default.
• W2143390187 cites W329959312 @default.
• W2143390187 doi "https://doi.org/10.1093/rheumatology/kel024" @default.
• W2143390187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16467367" @default.
• W2143390187 hasPublicationYear "2006" @default.
• W2143390187 type Work @default.
• W2143390187 sameAs 2143390187 @default.
• W2143390187 citedByCount "11" @default.
• W2143390187 countsByYear W21433901872015 @default.
• W2143390187 countsByYear W21433901872016 @default.
• W2143390187 countsByYear W21433901872019 @default.
• W2143390187 countsByYear W21433901872023 @default.
• W2143390187 crossrefType "journal-article" @default.
• W2143390187 hasAuthorship W2143390187A5009800567 @default.
• W2143390187 hasAuthorship W2143390187A5041932326 @default.
• W2143390187 hasAuthorship W2143390187A5051975326 @default.
• W2143390187 hasAuthorship W2143390187A5057660100 @default.
• W2143390187 hasAuthorship W2143390187A5059164931 @default.
• W2143390187 hasBestOaLocation W21433901871 @default.
• W2143390187 hasConcept C104317684 @default.
• W2143390187 hasConcept C105702510 @default.
• W2143390187 hasConcept C109523444 @default.
• W2143390187 hasConcept C11988809 @default.
• W2143390187 hasConcept C126322002 @default.
• W2143390187 hasConcept C142724271 @default.
• W2143390187 hasConcept C153911025 @default.
• W2143390187 hasConcept C189165786 @default.
• W2143390187 hasConcept C197534660 @default.
• W2143390187 hasConcept C203014093 @default.
• W2143390187 hasConcept C204787440 @default.
• W2143390187 hasConcept C2776164576 @default.
• W2143390187 hasConcept C2777667943 @default.
• W2143390187 hasConcept C2778690821 @default.
• W2143390187 hasConcept C2779335624 @default.
• W2143390187 hasConcept C2780550940 @default.
• W2143390187 hasConcept C2781121885 @default.
• W2143390187 hasConcept C3020332539 @default.
• W2143390187 hasConcept C55493867 @default.
• W2143390187 hasConcept C71924100 @default.
• W2143390187 hasConcept C86803240 @default.
• W2143390187 hasConcept C95444343 @default.
• W2143390187 hasConceptScore W2143390187C104317684 @default.
• W2143390187 hasConceptScore W2143390187C105702510 @default.

• next