FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143399059> ?p ?o ?g. }

• W2143399059 endingPage "2734" @default.
• W2143399059 startingPage "2728" @default.
• W2143399059 abstract "ABSTRACT Earlier studies showed that mice primed for a few hours with the trans -sialidase (TS) of Trypanosoma cruzi , the agent of Chagas' disease, become highly susceptible to trypanosomal infection. These studies suggest that TS affects parasite virulence independent of antigenic stimulation. Potentially, TS could enhance or reduce the virulence of heterologous microbes depending on the mechanism of TS action and on the type of immune response elicited by the particular parasite. We tested this hypothesis by expressing heterologous TS in Leishmania major , a protozoan parasite that causes cutaneous leishmaniasis and lacks TS and the TS product α2-3-linked sialic acid. Leishmania cells transfected with a T. cruzi TS expression construct made high levels of active enzyme, which was present in the promastigotes and shed into the extracellular milieu. TS expression did not affect L. major binding to and entry into cultured macrophages or its tropism for macrophage infection in vivo. However, TS-expressing L. major exhibited elevated virulence in BALB/c mice, as determined by lesion progression, parasite numbers, and macro- and microscopic examination of cutaneous lesions. Several genetic tests proved that the enhanced virulence was directly attributable to TS expression. The results are consistent with TS functioning to sabotage the mouse immune system to confer a growth advantage on T. cruzi and transgenic L. major . These data suggest that heterologous expression of T. cruzi virulence factors in Leishmania may provide a new approach for dissecting their function in vivo." @default.
• W2143399059 created "2016-06-24" @default.
• W2143399059 creator A5007063454 @default.
• W2143399059 creator A5007775851 @default.
• W2143399059 creator A5025154426 @default.
• W2143399059 creator A5028445292 @default.
• W2143399059 creator A5038908993 @default.
• W2143399059 creator A5087067580 @default.
• W2143399059 creator A5088715914 @default.
• W2143399059 date "2000-05-01" @default.
• W2143399059 modified "2023-10-06" @default.
• W2143399059 title "Heterologous Expression of<i>Trypanosoma cruzi trans</i>-Sialidase in<i>Leishmania major</i>Enhances Virulence" @default.
• W2143399059 cites W1580259448 @default.
• W2143399059 cites W1940901679 @default.
• W2143399059 cites W1973840257 @default.
• W2143399059 cites W1981242537 @default.
• W2143399059 cites W1998187743 @default.
• W2143399059 cites W2011097800 @default.
• W2143399059 cites W2027109238 @default.
• W2143399059 cites W2032746954 @default.
• W2143399059 cites W2034906512 @default.
• W2143399059 cites W2048673212 @default.
• W2143399059 cites W2056594886 @default.
• W2143399059 cites W2057327068 @default.
• W2143399059 cites W2060098125 @default.
• W2143399059 cites W2062640365 @default.
• W2143399059 cites W2082345749 @default.
• W2143399059 cites W2092527492 @default.
• W2143399059 cites W2092912450 @default.
• W2143399059 cites W2131152090 @default.
• W2143399059 cites W2132272258 @default.
• W2143399059 cites W2133157965 @default.
• W2143399059 cites W2133433426 @default.
• W2143399059 cites W2138931722 @default.
• W2143399059 cites W2147474208 @default.
• W2143399059 cites W2151091196 @default.
• W2143399059 cites W2156414842 @default.
• W2143399059 cites W2159642157 @default.
• W2143399059 cites W2161594864 @default.
• W2143399059 cites W2166983459 @default.
• W2143399059 cites W2168930459 @default.
• W2143399059 cites W4248772111 @default.
• W2143399059 doi "https://doi.org/10.1128/iai.68.5.2728-2734.2000" @default.
• W2143399059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/97481" @default.
• W2143399059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10768966" @default.
• W2143399059 hasPublicationYear "2000" @default.
• W2143399059 type Work @default.
• W2143399059 sameAs 2143399059 @default.
• W2143399059 citedByCount "41" @default.
• W2143399059 countsByYear W21433990592013 @default.
• W2143399059 countsByYear W21433990592016 @default.
• W2143399059 countsByYear W21433990592019 @default.
• W2143399059 countsByYear W21433990592020 @default.
• W2143399059 countsByYear W21433990592022 @default.
• W2143399059 crossrefType "journal-article" @default.
• W2143399059 hasAuthorship W2143399059A5007063454 @default.
• W2143399059 hasAuthorship W2143399059A5007775851 @default.
• W2143399059 hasAuthorship W2143399059A5025154426 @default.
• W2143399059 hasAuthorship W2143399059A5028445292 @default.
• W2143399059 hasAuthorship W2143399059A5038908993 @default.
• W2143399059 hasAuthorship W2143399059A5087067580 @default.
• W2143399059 hasAuthorship W2143399059A5088715914 @default.
• W2143399059 hasBestOaLocation W21433990592 @default.
• W2143399059 hasConcept C104317684 @default.
• W2143399059 hasConcept C108305142 @default.
• W2143399059 hasConcept C112418997 @default.
• W2143399059 hasConcept C136764020 @default.
• W2143399059 hasConcept C159047783 @default.
• W2143399059 hasConcept C203014093 @default.
• W2143399059 hasConcept C2777625466 @default.
• W2143399059 hasConcept C2779121891 @default.
• W2143399059 hasConcept C2780115692 @default.
• W2143399059 hasConcept C2780599195 @default.
• W2143399059 hasConcept C2781092759 @default.
• W2143399059 hasConcept C40767141 @default.
• W2143399059 hasConcept C41008148 @default.
• W2143399059 hasConcept C54355233 @default.
• W2143399059 hasConcept C60987743 @default.
• W2143399059 hasConcept C71928629 @default.
• W2143399059 hasConcept C86803240 @default.
• W2143399059 hasConcept C8891405 @default.
• W2143399059 hasConcept C89423630 @default.
• W2143399059 hasConcept C98319499 @default.
• W2143399059 hasConceptScore W2143399059C104317684 @default.
• W2143399059 hasConceptScore W2143399059C108305142 @default.
• W2143399059 hasConceptScore W2143399059C112418997 @default.
• W2143399059 hasConceptScore W2143399059C136764020 @default.
• W2143399059 hasConceptScore W2143399059C159047783 @default.
• W2143399059 hasConceptScore W2143399059C203014093 @default.
• W2143399059 hasConceptScore W2143399059C2777625466 @default.
• W2143399059 hasConceptScore W2143399059C2779121891 @default.
• W2143399059 hasConceptScore W2143399059C2780115692 @default.
• W2143399059 hasConceptScore W2143399059C2780599195 @default.
• W2143399059 hasConceptScore W2143399059C2781092759 @default.
• W2143399059 hasConceptScore W2143399059C40767141 @default.
• W2143399059 hasConceptScore W2143399059C41008148 @default.
• W2143399059 hasConceptScore W2143399059C54355233 @default.
• W2143399059 hasConceptScore W2143399059C60987743 @default.

• next