FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143400105> ?p ?o ?g. }

• W2143400105 endingPage "558" @default.
• W2143400105 startingPage "553" @default.
• W2143400105 abstract "Despite the recent emphasis on combination drug therapy for hypertension, little attention has been given to α/β blockade using agents other than labetalol. The purpose of this study was to 1) compare the efficacy of low-dose α/β blockade using doxazosin + betaxolol, versus monotherapy with an angiotensin converting enzyme inhibitor (quinapril) and a diuretic (hydrochlorothiazide [HCTZ]), and 2) assess the efficacy of low-dose doxazosin. In a crossover study, 21 hypertensive subjects were treated for 3 weeks each with HCTZ, 12.5 to 25 mg/day, quinapril, 10 to 40 mg/day, and a combination of doxazosin, 1 to 4 mg + betaxolol, 5 to 10 mg daily. Doses were titrated to achieve a systolic pressure <130 mm Hg, as assessed by self-recorded home measurements. Home blood pressure decreased 11.5/7.5 mm Hg after HCTZ, 12.9/8.8 mm Hg after quinapril, and 21.2/16.5 mm Hg after doxazosin + betaxolol (P < .001/< .001 v HCTZ and P < .002/< .001 v quinapril). The target systolic pressure was achieved by 33%, 43%, and 71% of subjects, respectively (P = .04 v HCTZ, and .03 v quinapril). Among the 8 subjects in whom doxazosin dosage was increased to the maximum of 4 mg, the mean blood pressure achieved at 4 mg did not differ from that achieved at 2 mg (136/87 v 136/88 mm Hg). We conclude that oral α/β blockade is superior to monotherapy with an angiotensin converting enzyme inhibitor or a diuretic and that maximal or near maximal efficacy can be achieved at a 2-mg dose of doxazosin. Low-dose oral α/β blockade merits greater consideration in the drug therapy of essential hypertension. Am J Hypertens 2001;14:553–558 © 2001 American Journal of Hypertension, Ltd." @default.
• W2143400105 created "2016-06-24" @default.
• W2143400105 creator A5004794575 @default.
• W2143400105 creator A5080118718 @default.
• W2143400105 date "2001-06-01" @default.
• W2143400105 modified "2023-09-23" @default.
• W2143400105 title "Low-dose α/β blockade in the treatment of essential hypertension" @default.
• W2143400105 cites W1891490391 @default.
• W2143400105 cites W1971826253 @default.
• W2143400105 cites W1981876523 @default.
• W2143400105 cites W1996206532 @default.
• W2143400105 cites W2004418464 @default.
• W2143400105 cites W2013016047 @default.
• W2143400105 cites W2022304784 @default.
• W2143400105 cites W2035367348 @default.
• W2143400105 cites W2042257745 @default.
• W2143400105 cites W2045202208 @default.
• W2143400105 cites W2056350582 @default.
• W2143400105 cites W2056626142 @default.
• W2143400105 cites W2063532711 @default.
• W2143400105 cites W2066617347 @default.
• W2143400105 cites W2071973601 @default.
• W2143400105 cites W2077171413 @default.
• W2143400105 cites W2078109769 @default.
• W2143400105 cites W2084422147 @default.
• W2143400105 cites W2099567527 @default.
• W2143400105 cites W2107561109 @default.
• W2143400105 cites W2116627666 @default.
• W2143400105 cites W2138795603 @default.
• W2143400105 cites W2143229385 @default.
• W2143400105 cites W2318174853 @default.
• W2143400105 cites W2608915729 @default.
• W2143400105 cites W2021839082 @default.
• W2143400105 doi "https://doi.org/10.1016/s0895-7061(00)01302-9" @default.
• W2143400105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11411735" @default.
• W2143400105 hasPublicationYear "2001" @default.
• W2143400105 type Work @default.
• W2143400105 sameAs 2143400105 @default.
• W2143400105 citedByCount "18" @default.
• W2143400105 countsByYear W21434001052012 @default.
• W2143400105 countsByYear W21434001052015 @default.
• W2143400105 countsByYear W21434001052017 @default.
• W2143400105 countsByYear W21434001052018 @default.
• W2143400105 crossrefType "journal-article" @default.
• W2143400105 hasAuthorship W2143400105A5004794575 @default.
• W2143400105 hasAuthorship W2143400105A5080118718 @default.
• W2143400105 hasBestOaLocation W21434001051 @default.
• W2143400105 hasConcept C126322002 @default.
• W2143400105 hasConcept C126894567 @default.
• W2143400105 hasConcept C141071460 @default.
• W2143400105 hasConcept C142724271 @default.
• W2143400105 hasConcept C204787440 @default.
• W2143400105 hasConcept C27016395 @default.
• W2143400105 hasConcept C27081682 @default.
• W2143400105 hasConcept C2776525901 @default.
• W2143400105 hasConcept C2776992270 @default.
• W2143400105 hasConcept C2777590997 @default.
• W2143400105 hasConcept C2778073030 @default.
• W2143400105 hasConcept C2779611605 @default.
• W2143400105 hasConcept C2779918671 @default.
• W2143400105 hasConcept C2779938033 @default.
• W2143400105 hasConcept C2780361556 @default.
• W2143400105 hasConcept C2781092963 @default.
• W2143400105 hasConcept C71924100 @default.
• W2143400105 hasConcept C84393581 @default.
• W2143400105 hasConcept C87813604 @default.
• W2143400105 hasConcept C98274493 @default.
• W2143400105 hasConceptScore W2143400105C126322002 @default.
• W2143400105 hasConceptScore W2143400105C126894567 @default.
• W2143400105 hasConceptScore W2143400105C141071460 @default.
• W2143400105 hasConceptScore W2143400105C142724271 @default.
• W2143400105 hasConceptScore W2143400105C204787440 @default.
• W2143400105 hasConceptScore W2143400105C27016395 @default.
• W2143400105 hasConceptScore W2143400105C27081682 @default.
• W2143400105 hasConceptScore W2143400105C2776525901 @default.
• W2143400105 hasConceptScore W2143400105C2776992270 @default.
• W2143400105 hasConceptScore W2143400105C2777590997 @default.
• W2143400105 hasConceptScore W2143400105C2778073030 @default.
• W2143400105 hasConceptScore W2143400105C2779611605 @default.
• W2143400105 hasConceptScore W2143400105C2779918671 @default.
• W2143400105 hasConceptScore W2143400105C2779938033 @default.
• W2143400105 hasConceptScore W2143400105C2780361556 @default.
• W2143400105 hasConceptScore W2143400105C2781092963 @default.
• W2143400105 hasConceptScore W2143400105C71924100 @default.
• W2143400105 hasConceptScore W2143400105C84393581 @default.
• W2143400105 hasConceptScore W2143400105C87813604 @default.
• W2143400105 hasConceptScore W2143400105C98274493 @default.
• W2143400105 hasIssue "6" @default.
• W2143400105 hasLocation W21434001051 @default.
• W2143400105 hasLocation W21434001052 @default.
• W2143400105 hasOpenAccess W2143400105 @default.
• W2143400105 hasPrimaryLocation W21434001051 @default.
• W2143400105 hasRelatedWork W171595136 @default.
• W2143400105 hasRelatedWork W1797367453 @default.
• W2143400105 hasRelatedWork W1972879340 @default.
• W2143400105 hasRelatedWork W2077861849 @default.
• W2143400105 hasRelatedWork W2125431201 @default.
• W2143400105 hasRelatedWork W2143400105 @default.

• next