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- W2143403799 abstract "Summary Maintenance of the intracellular homeostasis of metal ions is important for the virulence of many bacterial pathogens. Here, we demonstrate that the czcD gene of the human pathogen Streptococcus pneumoniae is involved in resistance against Zn 2+ , and that its transcription is induced by the transition‐metal ions Zn 2+ , Co 2+ and Ni 2+ . Upstream of czcD a gene was identified, encoding a novel TetR family regulator, SczA, that is responsible for the metal ion‐dependent activation of czcD expression. Transcriptome analyses revealed that in a sczA mutant expression of czcD , a gene encoding a MerR‐family transcriptional regulator and a gene encoding a zinc‐containing alcohol dehydrogenase ( adhB ) were downregulated. Activation of the czcD promoter by SczA is shown to proceed by Zn 2+ ‐dependent binding of SczA to a conserved DNA motif. In the absence of Zn 2+ , SczA binds to a second site in the czcD promoter, thereby fully blocking czcD expression. This is the first example of a metalloregulatory protein belonging to the TetR family that has been described. The presence in S. pneumoniae of the Zn 2+ ‐resistance system characterized in this study might reflect the need for adjustment to a fluctuating Zn 2+ pool encountered by this pathogen during infection of the human body." @default.
- W2143403799 created "2016-06-24" @default.
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- W2143403799 date "2007-07-19" @default.
- W2143403799 modified "2023-10-11" @default.
- W2143403799 title "The novel transcriptional regulator SczA mediates protection against Zn<sup>2+</sup> stress by activation of the Zn<sup>2+</sup>‐resistance gene <i>czcD</i> in <i>Streptococcus pneumoniae</i>" @default.
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- W2143403799 doi "https://doi.org/10.1111/j.1365-2958.2007.05849.x" @default.
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