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• W2143404468 abstract "ABSTRACT Coccidian parasites are transmitted via a fecal oocyst stage that is exceptionally resistant to environmental stress and harsh chemical treatments, which allows parasites to stably persist outside a host. Because of its oocyst durability Cryptosporidium parvum is a significant water- and food-borne pathogen of humans, as well as animals of agricultural importance. To date, only one apicomplexan oocyst membrane protein has been identified, Cryptosporidium oocyst wall protein 1 (COWP1). COWP1 has a highly cysteine-rich periodicity due to arrays of two apicomplexan-specific motifs, designated the type I and type II domains. In this study, exhaustive BLAST screening of a complete C. parvum genome sequence database resulted in identification of eight additional genes encoding similar arrays of cysteine-rich type I and/or type II domains. Transcript expression analysis revealed that all COWP genes are abundantly expressed at a time when developing oocysts are observed, roughly 48 to 72 h after inoculation of in vitro cultures. A monoclonal antibody recognizing COWP8 specifically localized to the C. parvum oocyst wall, supporting the hypothesis that multiple COWPs play a role in the oocyst wall structure. BLAST screening of the Toxoplasma gondii genome sequence database resulted in identification of a gene encoding at least one COWP homolog ( Tg OWP1), and this multiexon sequence information was used to isolate a full-length cDNA. Exhaustive screening of Plasmodium sp. genome sequence databases by using COWP genes as BLAST queries failed to detect similar proteins in Plasmodium . We therefore propose that the COWP family of proteins have a structural role in apicomplexan species that produce durable shed cysts capable of surviving environmental stress." @default.
• W2143404468 created "2016-06-24" @default.
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• W2143404468 date "2004-02-01" @default.
• W2143404468 modified "2023-10-16" @default.
• W2143404468 title "The <i>Cryptosporidium</i> Oocyst Wall Protein Is a Member of a Multigene Family and Has a Homolog in <i>Toxoplasma</i>" @default.
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• W2143404468 doi "https://doi.org/10.1128/iai.72.2.980-987.2004" @default.
• W2143404468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/321576" @default.
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