FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143404867> ?p ?o ?g. }

• W2143404867 endingPage "188" @default.
• W2143404867 startingPage "182" @default.
• W2143404867 abstract "The in vitro stability of cocaine in horse blood, sheep vitreous humour (VH) and homogenised deer muscle is described. The stability of cocaine in horse blood was of interest because many toxicology laboratories utilise horse blood for the preparation of calibration and check standards and the latter are typically stored during routine use. The storage stability of cocaine in human VH and muscle has not been previously reported. In the absence of blank human VH and muscle, cocaine stability under varying conditions was demonstrated in animal tissues. Blood and VH were stored with and without addition of NaF at room temperature (RT), 4 °C and −18 °C for 84 days. Muscle homogenates were prepared in water, water/2% NaF, and phosphate buffer (pH 6.0)/2% NaF, and stored for 31 days at RT, 4 °C and −18 °C. Cocaine stability in human muscle obtained from cocaine positive forensic cases was assessed following storage at −18 °C for 13 months. Cocaine and benzoylecgonine (BZE) were extracted using SPE and quantified by GC-MS/MS. Cocaine was stable for 7 days in refrigerated (4 °C) horse blood fortified with 1 and 2% NaF. In the absence of NaF, cocaine was not detectable by day 7 in blood stored at RT and 4 °C and had declined by 81% following storage at −18 °C. At 4 °C the rate of cocaine degradation in blood preserved with 2% NaF was significantly slower than with 1% NaF. The stability of cocaine in horse blood appeared to be less than that reported for human blood, probably attributable to the presence of carboxylesterase in horse plasma. Cocaine stored in VH at −18 °C was essentially stable for the study period whereas at 4 °C concentrations decreased by >50% in preserved and unpreserved VH stored for longer than 14 days. Fluoride did not significantly affect cocaine stability in VH. The stability of cocaine in muscle tissue homogenates significantly exceeded that in blood and VH at every temperature. In preserved and unpreserved samples stored at 4 °C and below, cocaine loss did not exceed 2%. The increased stability of cocaine in muscle was attributed to the low initial pH of post-mortem muscle. In tissue from one human case stored for 13 months at −18 °C the muscle cocaine concentration declined by only 15% (range: 5–22%). These findings promote the use of human muscle as a toxicological specimen in which cocaine may be detected for longer compared with blood or VH." @default.
• W2143404867 created "2016-06-24" @default.
• W2143404867 creator A5006096963 @default.
• W2143404867 creator A5014233923 @default.
• W2143404867 creator A5024071994 @default.
• W2143404867 creator A5043245878 @default.
• W2143404867 creator A5044110885 @default.
• W2143404867 creator A5060093569 @default.
• W2143404867 creator A5077633500 @default.
• W2143404867 date "2012-04-01" @default.
• W2143404867 modified "2023-09-25" @default.
• W2143404867 title "The effect of sodium fluoride preservative and storage temperature on the stability of cocaine in horse blood, sheep vitreous and deer muscle" @default.
• W2143404867 cites W1519437292 @default.
• W2143404867 cites W1557792365 @default.
• W2143404867 cites W1602460289 @default.
• W2143404867 cites W1778297333 @default.
• W2143404867 cites W1809000693 @default.
• W2143404867 cites W1964659102 @default.
• W2143404867 cites W1971008344 @default.
• W2143404867 cites W1978215280 @default.
• W2143404867 cites W1987688891 @default.
• W2143404867 cites W1988753196 @default.
• W2143404867 cites W1991966027 @default.
• W2143404867 cites W1992878578 @default.
• W2143404867 cites W2015775041 @default.
• W2143404867 cites W2039285866 @default.
• W2143404867 cites W2055573003 @default.
• W2143404867 cites W2055603497 @default.
• W2143404867 cites W2061014349 @default.
• W2143404867 cites W2061088388 @default.
• W2143404867 cites W2088133477 @default.
• W2143404867 cites W2118141474 @default.
• W2143404867 cites W2120523090 @default.
• W2143404867 cites W2132087679 @default.
• W2143404867 cites W2137699914 @default.
• W2143404867 cites W2139491736 @default.
• W2143404867 cites W2142596187 @default.
• W2143404867 cites W2153843283 @default.
• W2143404867 cites W2156890309 @default.
• W2143404867 cites W245916294 @default.
• W2143404867 cites W326010155 @default.
• W2143404867 cites W4239912167 @default.
• W2143404867 cites W68624106 @default.
• W2143404867 doi "https://doi.org/10.1016/j.forsciint.2011.11.001" @default.
• W2143404867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22185827" @default.
• W2143404867 hasPublicationYear "2012" @default.
• W2143404867 type Work @default.
• W2143404867 sameAs 2143404867 @default.
• W2143404867 citedByCount "28" @default.
• W2143404867 countsByYear W21434048672012 @default.
• W2143404867 countsByYear W21434048672013 @default.
• W2143404867 countsByYear W21434048672014 @default.
• W2143404867 countsByYear W21434048672015 @default.
• W2143404867 countsByYear W21434048672016 @default.
• W2143404867 countsByYear W21434048672017 @default.
• W2143404867 countsByYear W21434048672018 @default.
• W2143404867 countsByYear W21434048672020 @default.
• W2143404867 countsByYear W21434048672021 @default.
• W2143404867 countsByYear W21434048672022 @default.
• W2143404867 countsByYear W21434048672023 @default.
• W2143404867 crossrefType "journal-article" @default.
• W2143404867 hasAuthorship W2143404867A5006096963 @default.
• W2143404867 hasAuthorship W2143404867A5014233923 @default.
• W2143404867 hasAuthorship W2143404867A5024071994 @default.
• W2143404867 hasAuthorship W2143404867A5043245878 @default.
• W2143404867 hasAuthorship W2143404867A5044110885 @default.
• W2143404867 hasAuthorship W2143404867A5060093569 @default.
• W2143404867 hasAuthorship W2143404867A5077633500 @default.
• W2143404867 hasConcept C151730666 @default.
• W2143404867 hasConcept C185592680 @default.
• W2143404867 hasConcept C2777477808 @default.
• W2143404867 hasConcept C2777537440 @default.
• W2143404867 hasConcept C2780762169 @default.
• W2143404867 hasConcept C31903555 @default.
• W2143404867 hasConcept C43617362 @default.
• W2143404867 hasConcept C55493867 @default.
• W2143404867 hasConcept C67031304 @default.
• W2143404867 hasConcept C71924100 @default.
• W2143404867 hasConcept C86803240 @default.
• W2143404867 hasConceptScore W2143404867C151730666 @default.
• W2143404867 hasConceptScore W2143404867C185592680 @default.
• W2143404867 hasConceptScore W2143404867C2777477808 @default.
• W2143404867 hasConceptScore W2143404867C2777537440 @default.
• W2143404867 hasConceptScore W2143404867C2780762169 @default.
• W2143404867 hasConceptScore W2143404867C31903555 @default.
• W2143404867 hasConceptScore W2143404867C43617362 @default.
• W2143404867 hasConceptScore W2143404867C55493867 @default.
• W2143404867 hasConceptScore W2143404867C67031304 @default.
• W2143404867 hasConceptScore W2143404867C71924100 @default.
• W2143404867 hasConceptScore W2143404867C86803240 @default.
• W2143404867 hasIssue "1-3" @default.
• W2143404867 hasLocation W21434048671 @default.
• W2143404867 hasLocation W21434048672 @default.
• W2143404867 hasOpenAccess W2143404867 @default.
• W2143404867 hasPrimaryLocation W21434048671 @default.
• W2143404867 hasRelatedWork W1979741826 @default.
• W2143404867 hasRelatedWork W1994885846 @default.
• W2143404867 hasRelatedWork W2015187480 @default.

• next