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• W2143406977 endingPage "281" @default.
• W2143406977 startingPage "267" @default.
• W2143406977 abstract "Acinar cells of the pancreas produce the majority of enzymes required for digestion and make up >90% of the cells within the pancreas. Due to a common developmental origin and the plastic nature of the acinar cell phenotype, these cells have been identified as a possible source of β cells as a therapeutic option for Type I diabetes. However, recent evidence indicates that acinar cells are the main source of pancreatic intraepithelial neoplasias (PanINs), the predecessor of pancreatic ductal adenocarcinoma (PDAC). The conversion of acinar cells to either β cells or precursors to PDAC is dependent on reprogramming of the cells to a more primitive, progenitor-like phenotype, which involves changes in transcription factor expression and activity, and changes in their epigenetic program. This review will focus on the mechanisms that promote acinar cell reprogramming, as well as the factors that may affect these mechanisms." @default.
• W2143406977 created "2016-06-24" @default.
• W2143406977 creator A5042681178 @default.
• W2143406977 creator A5047964091 @default.
• W2143406977 creator A5076417845 @default.
• W2143406977 date "2015-04-01" @default.
• W2143406977 modified "2023-10-15" @default.
• W2143406977 title "Acinar cell reprogramming: a clinically important target in pancreatic disease" @default.
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