Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143411942> ?p ?o ?g. }
- W2143411942 endingPage "2671" @default.
- W2143411942 startingPage "2661" @default.
- W2143411942 abstract "Insulin resistance is accompanied by hyperinsulinemia and activation of the renin-angiotensin system, both of which are associated with hypertension. Because the kidney plays a major role in the regulation of blood pressure, we studied the regulation of insulin receptor expression in the kidney during states of insulin resistance. Using two rat models of insulin resistance, Western blot analysis demonstrated a significant reduction in the expression of insulin receptor subunits in the kidney compared to lean control rats. Treatment of insulin resistance in Zucker rats with the insulin-sensitizing drug rosiglitazone partially restored renal insulin receptor levels. Conversely, treatment with the angiotensin II type 1 receptor (AT1) antagonist candesartan increased renal insulin receptor expression compared to untreated rats. Streptozotocin-induced hyperglycemia, which results from hypoinsulinemia, reduced expression of renal insulin receptors. Hyperinsulinemia induced by insulin infusion, however, did not produce a similar effect. In conclusion, insulin receptors are downregulated in the kidneys of insulin resistant rats, possibly mediated by hyperglycemia and angiotensin II." @default.
- W2143411942 created "2016-06-24" @default.
- W2143411942 creator A5002898077 @default.
- W2143411942 creator A5016797401 @default.
- W2143411942 creator A5060168386 @default.
- W2143411942 creator A5069984517 @default.
- W2143411942 creator A5085417686 @default.
- W2143411942 date "2007-10-01" @default.
- W2143411942 modified "2023-09-25" @default.
- W2143411942 title "Reduced Expression of Insulin Receptors in the Kidneys of Insulin-Resistant Rats" @default.
- W2143411942 cites W1522518804 @default.
- W2143411942 cites W1544564931 @default.
- W2143411942 cites W1818300518 @default.
- W2143411942 cites W1971422032 @default.
- W2143411942 cites W1973289473 @default.
- W2143411942 cites W1974115143 @default.
- W2143411942 cites W1991710558 @default.
- W2143411942 cites W1993456360 @default.
- W2143411942 cites W2002343239 @default.
- W2143411942 cites W2008806257 @default.
- W2143411942 cites W2016667519 @default.
- W2143411942 cites W2017766022 @default.
- W2143411942 cites W2024504227 @default.
- W2143411942 cites W2048334412 @default.
- W2143411942 cites W2054704564 @default.
- W2143411942 cites W2069711524 @default.
- W2143411942 cites W2070705505 @default.
- W2143411942 cites W2095836366 @default.
- W2143411942 cites W2097160762 @default.
- W2143411942 cites W2098527497 @default.
- W2143411942 cites W2114920731 @default.
- W2143411942 cites W2116990482 @default.
- W2143411942 cites W2118434501 @default.
- W2143411942 cites W2126273647 @default.
- W2143411942 cites W2136163378 @default.
- W2143411942 cites W2140699761 @default.
- W2143411942 cites W2145071454 @default.
- W2143411942 cites W2146405327 @default.
- W2143411942 cites W2163564256 @default.
- W2143411942 cites W2177335585 @default.
- W2143411942 cites W2398881183 @default.
- W2143411942 cites W4237481948 @default.
- W2143411942 doi "https://doi.org/10.1681/asn.2006121410" @default.
- W2143411942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17855644" @default.
- W2143411942 hasPublicationYear "2007" @default.
- W2143411942 type Work @default.
- W2143411942 sameAs 2143411942 @default.
- W2143411942 citedByCount "80" @default.
- W2143411942 countsByYear W21434119422012 @default.
- W2143411942 countsByYear W21434119422013 @default.
- W2143411942 countsByYear W21434119422014 @default.
- W2143411942 countsByYear W21434119422015 @default.
- W2143411942 countsByYear W21434119422016 @default.
- W2143411942 countsByYear W21434119422017 @default.
- W2143411942 countsByYear W21434119422018 @default.
- W2143411942 countsByYear W21434119422019 @default.
- W2143411942 countsByYear W21434119422020 @default.
- W2143411942 countsByYear W21434119422021 @default.
- W2143411942 countsByYear W21434119422022 @default.
- W2143411942 countsByYear W21434119422023 @default.
- W2143411942 crossrefType "journal-article" @default.
- W2143411942 hasAuthorship W2143411942A5002898077 @default.
- W2143411942 hasAuthorship W2143411942A5016797401 @default.
- W2143411942 hasAuthorship W2143411942A5060168386 @default.
- W2143411942 hasAuthorship W2143411942A5069984517 @default.
- W2143411942 hasAuthorship W2143411942A5085417686 @default.
- W2143411942 hasBestOaLocation W21434119421 @default.
- W2143411942 hasConcept C112446052 @default.
- W2143411942 hasConcept C123915805 @default.
- W2143411942 hasConcept C126322002 @default.
- W2143411942 hasConcept C134018914 @default.
- W2143411942 hasConcept C170493617 @default.
- W2143411942 hasConcept C2777391703 @default.
- W2143411942 hasConcept C2779306644 @default.
- W2143411942 hasConcept C2780036600 @default.
- W2143411942 hasConcept C2780091579 @default.
- W2143411942 hasConcept C2780988686 @default.
- W2143411942 hasConcept C2908929049 @default.
- W2143411942 hasConcept C71924100 @default.
- W2143411942 hasConceptScore W2143411942C112446052 @default.
- W2143411942 hasConceptScore W2143411942C123915805 @default.
- W2143411942 hasConceptScore W2143411942C126322002 @default.
- W2143411942 hasConceptScore W2143411942C134018914 @default.
- W2143411942 hasConceptScore W2143411942C170493617 @default.
- W2143411942 hasConceptScore W2143411942C2777391703 @default.
- W2143411942 hasConceptScore W2143411942C2779306644 @default.
- W2143411942 hasConceptScore W2143411942C2780036600 @default.
- W2143411942 hasConceptScore W2143411942C2780091579 @default.
- W2143411942 hasConceptScore W2143411942C2780988686 @default.
- W2143411942 hasConceptScore W2143411942C2908929049 @default.
- W2143411942 hasConceptScore W2143411942C71924100 @default.
- W2143411942 hasIssue "10" @default.
- W2143411942 hasLocation W21434119421 @default.
- W2143411942 hasLocation W21434119422 @default.
- W2143411942 hasLocation W21434119423 @default.
- W2143411942 hasOpenAccess W2143411942 @default.
- W2143411942 hasPrimaryLocation W21434119421 @default.
- W2143411942 hasRelatedWork W1991367927 @default.