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- W2143412253 abstract "Abstract Purpose: This study aimed to develop an efficient and safe strategy to introduce suicide genes into colon cancer cells. Experimental Design: In this study, we fused an enhanced carcinoembryonic antigen promoter (CEA) to a suicide gene, cytosine deaminase (CD). This construct was delivered into colon cancer cells using calcium phosphate nanoparticles (CPNP). The cells were then treated with the prodrug 5-FC. The therapeutic effect was evaluated in vitro and in vivo. Results: Our study showed that the CEA promoter–driven, CPNP-delivered suicide gene was only expressed in CEA-positive colon cancer cells, and resulted in significant cytotoxicity after administration of the prodrug 5-FC in vitro. Moreover, our in vivo study showed that CPNP-mediated CEA-CD delivery, together with 5-FC treatment, resulted in significant tumor growth delay in xenograft human colon carcinoma. Conclusions: Our study indicates that the combination of CPNP and CEA-CD gene expression represents a novel approach for CEA-positive tumor gene therapy." @default.
- W2143412253 created "2016-06-24" @default.
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- W2143412253 date "2008-12-31" @default.
- W2143412253 modified "2023-09-23" @default.
- W2143412253 title "Tissue Specific Cytotoxicity of Colon Cancer Cells Mediated by Nanoparticle-delivered Suicide Gene <i>In vitro</i> and <i>In vivo</i>" @default.
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- W2143412253 doi "https://doi.org/10.1158/1078-0432.ccr-08-1094" @default.
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