FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143417246> ?p ?o ?g. }

• W2143417246 endingPage "1773" @default.
• W2143417246 startingPage "1767" @default.
• W2143417246 abstract "We determined if alveolar macrophages (AMs) from infants with severe recurrent wheezing episodes release increased amounts of tumour necrosis factor-alpha (TNF-alpha), as described in adults with asthma. We compared TNF-alpha release by unstimulated and lipopolysaccharide-stimulated AMs obtained by bronchoalveolar lavage in 13 wheezy and seven nonwheezy infants (aged 6-36 months) and analysed its regulation by dexamethasone. Metabolites in cell supernatants were quantified by enzyme-linked immunosorbent assay (ELISA) (TNF-alpha) or radioimmunoassay (thromboxane B2 and prostaglandin E2). Comparison of results was performed by the Mann-Whitney U-test and values were expressed as median (interquartile range) in ng x 10(6) cells(-1). Resting AMs from wheezy infants released larger amounts of TNF-alpha and thromboxane B2 as compared to controls: 2.67 (0.89-8.33) vs 0.48 (0.25-1.08) and 75.63 (38.07-158.91) vs 10.03 (7.36-76.08), respectively (p<0.05). When stimulated overnight with bacterial lipopolysaccharide, AMs from both groups released similar amounts of metabolites. Dexamethasone induced a consistent inhibition of the lipopolysaccharide-stimulated release of all the mediators. Our results show that alveolar macrophages from wheezy infants are activated to release increased amounts of tumour necrosis factor-alpha, as in asthma, and suggest that infants with recurrent wheezing may eventually benefit from treatment with glucocorticoids." @default.
• W2143417246 created "2016-06-24" @default.
• W2143417246 creator A5002879812 @default.
• W2143417246 creator A5005069685 @default.
• W2143417246 creator A5010494222 @default.
• W2143417246 creator A5032401091 @default.
• W2143417246 creator A5059515482 @default.
• W2143417246 creator A5066530416 @default.
• W2143417246 date "1997-08-01" @default.
• W2143417246 modified "2023-10-16" @default.
• W2143417246 title "Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants" @default.
• W2143417246 cites W1902360293 @default.
• W2143417246 cites W1956369936 @default.
• W2143417246 cites W1976466497 @default.
• W2143417246 cites W1981811832 @default.
• W2143417246 cites W1982725712 @default.
• W2143417246 cites W2002858848 @default.
• W2143417246 cites W2012253460 @default.
• W2143417246 cites W2012344926 @default.
• W2143417246 cites W2016532478 @default.
• W2143417246 cites W2017013436 @default.
• W2143417246 cites W2018186263 @default.
• W2143417246 cites W2032064406 @default.
• W2143417246 cites W2032077695 @default.
• W2143417246 cites W2041102059 @default.
• W2143417246 cites W2047980607 @default.
• W2143417246 cites W2052140026 @default.
• W2143417246 cites W2056278996 @default.
• W2143417246 cites W2060829699 @default.
• W2143417246 cites W2062611291 @default.
• W2143417246 cites W2066532598 @default.
• W2143417246 cites W2096856726 @default.
• W2143417246 cites W2097646128 @default.
• W2143417246 cites W2113509262 @default.
• W2143417246 cites W2116656764 @default.
• W2143417246 cites W2143590308 @default.
• W2143417246 cites W2145742564 @default.
• W2143417246 cites W2150977028 @default.
• W2143417246 cites W2155620034 @default.
• W2143417246 cites W2164974807 @default.
• W2143417246 cites W2172009888 @default.
• W2143417246 cites W2312397711 @default.
• W2143417246 cites W29647042 @default.
• W2143417246 cites W2055366481 @default.
• W2143417246 doi "https://doi.org/10.1183/09031936.97.10081767" @default.
• W2143417246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9272917" @default.
• W2143417246 hasPublicationYear "1997" @default.
• W2143417246 type Work @default.
• W2143417246 sameAs 2143417246 @default.
• W2143417246 citedByCount "51" @default.
• W2143417246 countsByYear W21434172462013 @default.
• W2143417246 countsByYear W21434172462017 @default.
• W2143417246 countsByYear W21434172462019 @default.
• W2143417246 crossrefType "journal-article" @default.
• W2143417246 hasAuthorship W2143417246A5002879812 @default.
• W2143417246 hasAuthorship W2143417246A5005069685 @default.
• W2143417246 hasAuthorship W2143417246A5010494222 @default.
• W2143417246 hasAuthorship W2143417246A5032401091 @default.
• W2143417246 hasAuthorship W2143417246A5059515482 @default.
• W2143417246 hasAuthorship W2143417246A5066530416 @default.
• W2143417246 hasBestOaLocation W21434172461 @default.
• W2143417246 hasConcept C126322002 @default.
• W2143417246 hasConcept C134018914 @default.
• W2143417246 hasConcept C141071460 @default.
• W2143417246 hasConcept C176685330 @default.
• W2143417246 hasConcept C17991360 @default.
• W2143417246 hasConcept C203014093 @default.
• W2143417246 hasConcept C2775944032 @default.
• W2143417246 hasConcept C2776178081 @default.
• W2143417246 hasConcept C2777714996 @default.
• W2143417246 hasConcept C2777956040 @default.
• W2143417246 hasConcept C2777961210 @default.
• W2143417246 hasConcept C2778543330 @default.
• W2143417246 hasConcept C2778754761 @default.
• W2143417246 hasConcept C2780401358 @default.
• W2143417246 hasConcept C2781080829 @default.
• W2143417246 hasConcept C49453240 @default.
• W2143417246 hasConcept C64943373 @default.
• W2143417246 hasConcept C71924100 @default.
• W2143417246 hasConcept C89560881 @default.
• W2143417246 hasConceptScore W2143417246C126322002 @default.
• W2143417246 hasConceptScore W2143417246C134018914 @default.
• W2143417246 hasConceptScore W2143417246C141071460 @default.
• W2143417246 hasConceptScore W2143417246C176685330 @default.
• W2143417246 hasConceptScore W2143417246C17991360 @default.
• W2143417246 hasConceptScore W2143417246C203014093 @default.
• W2143417246 hasConceptScore W2143417246C2775944032 @default.
• W2143417246 hasConceptScore W2143417246C2776178081 @default.
• W2143417246 hasConceptScore W2143417246C2777714996 @default.
• W2143417246 hasConceptScore W2143417246C2777956040 @default.
• W2143417246 hasConceptScore W2143417246C2777961210 @default.
• W2143417246 hasConceptScore W2143417246C2778543330 @default.
• W2143417246 hasConceptScore W2143417246C2778754761 @default.
• W2143417246 hasConceptScore W2143417246C2780401358 @default.
• W2143417246 hasConceptScore W2143417246C2781080829 @default.
• W2143417246 hasConceptScore W2143417246C49453240 @default.
• W2143417246 hasConceptScore W2143417246C64943373 @default.
• W2143417246 hasConceptScore W2143417246C71924100 @default.

• next