Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143446975> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2143446975 endingPage "471" @default.
- W2143446975 startingPage "467" @default.
- W2143446975 abstract "We studied the clinical features, laboratory investigation, management and natural history of a cohort of patients with Juvenile Parkinsonism (JP), seen at a tertiary referral centre. JP was defined as Parkinsonism with onset at age 20 years or less. Six patients (five male, one female) entered the study. The mean age at onset of Parkinsonism was 12.5 years (range 7-19) and the mean follow-up time was 49.3 months (range 40-57). Bradykinesia, rigidity, and postural instability were observed in all patients and five subjects had tremor. Dystonia was present in four subjects. Other clinical features were dementia (five subjects), supranuclear ophthalmoparesis (five subjects), seizures (three subjects), multifocal myoclonus (one subject), decreased deep reflexes (one subject), pyramidal signs (one subject). Family history of Parkinson's disease (PD) was positive in one subject. Work-up for Wilson's disease was negative in all patients. Neuroimaging studies showed cortical atrophy in two subjects and mild brainstem atrophy in two others. Sea-blue histiocytes were found in one subject. L-dopa improved the Parkinsonism in all subjects but four rapidly developed fluctuations and dyskinesias, requiring, in one, stereotaxic surgery. After a mean disease duration of 6.5 years, five subjects require assistance for performance of all daily activities. JP is a heterogeneous clinical entity. In the majority of patients, no underlying cause is identified. The unusual clinical features suggest most subjects have a CNS degenerative disease distinct from PD. There is, however, evidence suggesting that PD may rarely cause JP. Gangliosidosis is another cause of L-dopa-responsive JP. Regardless of the cause, in the present study JP displays an aggressive and rapidly progressive course in most patients." @default.
- W2143446975 created "2016-06-24" @default.
- W2143446975 creator A5013758684 @default.
- W2143446975 creator A5015655920 @default.
- W2143446975 date "2000-09-01" @default.
- W2143446975 modified "2023-10-03" @default.
- W2143446975 title "Juvenile Parkinsonism: a heterogeneous entity" @default.
- W2143446975 cites W1978140170 @default.
- W2143446975 cites W1981515077 @default.
- W2143446975 cites W1985299260 @default.
- W2143446975 cites W1990115112 @default.
- W2143446975 cites W2008560062 @default.
- W2143446975 cites W2010577688 @default.
- W2143446975 cites W2034076912 @default.
- W2143446975 cites W2036750918 @default.
- W2143446975 cites W2036758460 @default.
- W2143446975 cites W2038602274 @default.
- W2143446975 cites W2041694263 @default.
- W2143446975 cites W2083447600 @default.
- W2143446975 cites W2095111193 @default.
- W2143446975 cites W2139638246 @default.
- W2143446975 cites W2164781049 @default.
- W2143446975 cites W2247010700 @default.
- W2143446975 cites W2473580629 @default.
- W2143446975 cites W4375906958 @default.
- W2143446975 doi "https://doi.org/10.1046/j.1468-1331.2000.t01-1-00100.x" @default.
- W2143446975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11054129" @default.
- W2143446975 hasPublicationYear "2000" @default.
- W2143446975 type Work @default.
- W2143446975 sameAs 2143446975 @default.
- W2143446975 citedByCount "13" @default.
- W2143446975 countsByYear W21434469752012 @default.
- W2143446975 countsByYear W21434469752019 @default.
- W2143446975 countsByYear W21434469752020 @default.
- W2143446975 crossrefType "journal-article" @default.
- W2143446975 hasAuthorship W2143446975A5013758684 @default.
- W2143446975 hasAuthorship W2143446975A5015655920 @default.
- W2143446975 hasConcept C118552586 @default.
- W2143446975 hasConcept C126322002 @default.
- W2143446975 hasConcept C187212893 @default.
- W2143446975 hasConcept C2776477761 @default.
- W2143446975 hasConcept C2776525014 @default.
- W2143446975 hasConcept C2776538686 @default.
- W2143446975 hasConcept C2776622722 @default.
- W2143446975 hasConcept C2778559928 @default.
- W2143446975 hasConcept C2779134260 @default.
- W2143446975 hasConcept C2779483572 @default.
- W2143446975 hasConcept C2781172350 @default.
- W2143446975 hasConcept C3008058167 @default.
- W2143446975 hasConcept C524204448 @default.
- W2143446975 hasConcept C71924100 @default.
- W2143446975 hasConcept C72563966 @default.
- W2143446975 hasConceptScore W2143446975C118552586 @default.
- W2143446975 hasConceptScore W2143446975C126322002 @default.
- W2143446975 hasConceptScore W2143446975C187212893 @default.
- W2143446975 hasConceptScore W2143446975C2776477761 @default.
- W2143446975 hasConceptScore W2143446975C2776525014 @default.
- W2143446975 hasConceptScore W2143446975C2776538686 @default.
- W2143446975 hasConceptScore W2143446975C2776622722 @default.
- W2143446975 hasConceptScore W2143446975C2778559928 @default.
- W2143446975 hasConceptScore W2143446975C2779134260 @default.
- W2143446975 hasConceptScore W2143446975C2779483572 @default.
- W2143446975 hasConceptScore W2143446975C2781172350 @default.
- W2143446975 hasConceptScore W2143446975C3008058167 @default.
- W2143446975 hasConceptScore W2143446975C524204448 @default.
- W2143446975 hasConceptScore W2143446975C71924100 @default.
- W2143446975 hasConceptScore W2143446975C72563966 @default.
- W2143446975 hasIssue "5" @default.
- W2143446975 hasLocation W21434469751 @default.
- W2143446975 hasLocation W21434469752 @default.
- W2143446975 hasOpenAccess W2143446975 @default.
- W2143446975 hasPrimaryLocation W21434469751 @default.
- W2143446975 hasRelatedWork W1014111089 @default.
- W2143446975 hasRelatedWork W2072720323 @default.
- W2143446975 hasRelatedWork W2128950897 @default.
- W2143446975 hasRelatedWork W2409948100 @default.
- W2143446975 hasRelatedWork W2426878951 @default.
- W2143446975 hasRelatedWork W2587064098 @default.
- W2143446975 hasRelatedWork W3041791797 @default.
- W2143446975 hasRelatedWork W4235425724 @default.
- W2143446975 hasRelatedWork W4237396695 @default.
- W2143446975 hasRelatedWork W4241299060 @default.
- W2143446975 hasVolume "7" @default.
- W2143446975 isParatext "false" @default.
- W2143446975 isRetracted "false" @default.
- W2143446975 magId "2143446975" @default.
- W2143446975 workType "article" @default.