Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143448972> ?p ?o ?g. }
- W2143448972 endingPage "4827" @default.
- W2143448972 startingPage "4818" @default.
- W2143448972 abstract "Respiratory syncytial virus (RSV) is a major cause of severe respiratory disease in infants and calves. Bovine RSV (bRSV) is a natural pathogen for cattle, and bRSV infection in calves shares many features with the human infection. Thus, bRSV infection in cattle provides the ideal setting to evaluate the safety and efficacy of novel RSV vaccine strategies. Here, we have evaluated the efficacy and safety of modified vaccinia virus Ankara (rMVA)-based vaccine candidates, expressing the bovine RSV-F protein, either or not in combination with the G protein, in colostrums-deprived SPF calves born by caesarean section. Vaccination induced bRSV-specific IgG and CD8 T cell responses. Importantly, no IgE responses were detected. After bRSV challenge, rMVA vaccinated calves experienced less severe symptoms of lower respiratory tract disease compared to the mock-immunized control group. Immunized animals showed reduced pulmonary virus loads, and no eosinophilic infiltration or enhanced respiratory distress. In conclusion, candidate rMVA/bRSV vaccines induced protective and safe immune responses in calves." @default.
- W2143448972 created "2016-06-24" @default.
- W2143448972 creator A5023687974 @default.
- W2143448972 creator A5026443432 @default.
- W2143448972 creator A5032232009 @default.
- W2143448972 creator A5033482353 @default.
- W2143448972 creator A5044802160 @default.
- W2143448972 creator A5071588060 @default.
- W2143448972 creator A5079895348 @default.
- W2143448972 date "2007-06-01" @default.
- W2143448972 modified "2023-09-27" @default.
- W2143448972 title "Vaccination with recombinant modified vaccinia virus Ankara expressing bovine respiratory syncytial virus (bRSV) proteins protects calves against RSV challenge" @default.
- W2143448972 cites W123738112 @default.
- W2143448972 cites W142814393 @default.
- W2143448972 cites W1762988928 @default.
- W2143448972 cites W1843142289 @default.
- W2143448972 cites W1894593978 @default.
- W2143448972 cites W1913350003 @default.
- W2143448972 cites W1925238017 @default.
- W2143448972 cites W1964809239 @default.
- W2143448972 cites W1967880566 @default.
- W2143448972 cites W1971971926 @default.
- W2143448972 cites W1973187440 @default.
- W2143448972 cites W1973387722 @default.
- W2143448972 cites W1980267456 @default.
- W2143448972 cites W1989332140 @default.
- W2143448972 cites W1991443414 @default.
- W2143448972 cites W1993251450 @default.
- W2143448972 cites W1993564021 @default.
- W2143448972 cites W1995480296 @default.
- W2143448972 cites W2002846513 @default.
- W2143448972 cites W2003825364 @default.
- W2143448972 cites W2009907033 @default.
- W2143448972 cites W2012853657 @default.
- W2143448972 cites W2062096354 @default.
- W2143448972 cites W2063783399 @default.
- W2143448972 cites W2071150424 @default.
- W2143448972 cites W2073162537 @default.
- W2143448972 cites W2080740527 @default.
- W2143448972 cites W2083589191 @default.
- W2143448972 cites W2092732192 @default.
- W2143448972 cites W2095135796 @default.
- W2143448972 cites W2096620145 @default.
- W2143448972 cites W2097229561 @default.
- W2143448972 cites W2123817481 @default.
- W2143448972 cites W2134919119 @default.
- W2143448972 cites W2148546836 @default.
- W2143448972 cites W2153204305 @default.
- W2143448972 cites W2154235266 @default.
- W2143448972 cites W2164576579 @default.
- W2143448972 cites W2165261190 @default.
- W2143448972 cites W2184646877 @default.
- W2143448972 cites W2186462835 @default.
- W2143448972 cites W2384630539 @default.
- W2143448972 cites W4246881984 @default.
- W2143448972 doi "https://doi.org/10.1016/j.vaccine.2007.04.002" @default.
- W2143448972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17499893" @default.
- W2143448972 hasPublicationYear "2007" @default.
- W2143448972 type Work @default.
- W2143448972 sameAs 2143448972 @default.
- W2143448972 citedByCount "21" @default.
- W2143448972 countsByYear W21434489722012 @default.
- W2143448972 countsByYear W21434489722013 @default.
- W2143448972 countsByYear W21434489722014 @default.
- W2143448972 countsByYear W21434489722017 @default.
- W2143448972 countsByYear W21434489722018 @default.
- W2143448972 countsByYear W21434489722020 @default.
- W2143448972 countsByYear W21434489722021 @default.
- W2143448972 crossrefType "journal-article" @default.
- W2143448972 hasAuthorship W2143448972A5023687974 @default.
- W2143448972 hasAuthorship W2143448972A5026443432 @default.
- W2143448972 hasAuthorship W2143448972A5032232009 @default.
- W2143448972 hasAuthorship W2143448972A5033482353 @default.
- W2143448972 hasAuthorship W2143448972A5044802160 @default.
- W2143448972 hasAuthorship W2143448972A5071588060 @default.
- W2143448972 hasAuthorship W2143448972A5079895348 @default.
- W2143448972 hasConcept C104317684 @default.
- W2143448972 hasConcept C159047783 @default.
- W2143448972 hasConcept C203014093 @default.
- W2143448972 hasConcept C22070199 @default.
- W2143448972 hasConcept C2522874641 @default.
- W2143448972 hasConcept C2780355102 @default.
- W2143448972 hasConcept C2780727368 @default.
- W2143448972 hasConcept C2780813555 @default.
- W2143448972 hasConcept C2781356689 @default.
- W2143448972 hasConcept C40767141 @default.
- W2143448972 hasConcept C55493867 @default.
- W2143448972 hasConcept C71924100 @default.
- W2143448972 hasConcept C86803240 @default.
- W2143448972 hasConceptScore W2143448972C104317684 @default.
- W2143448972 hasConceptScore W2143448972C159047783 @default.
- W2143448972 hasConceptScore W2143448972C203014093 @default.
- W2143448972 hasConceptScore W2143448972C22070199 @default.
- W2143448972 hasConceptScore W2143448972C2522874641 @default.
- W2143448972 hasConceptScore W2143448972C2780355102 @default.
- W2143448972 hasConceptScore W2143448972C2780727368 @default.
- W2143448972 hasConceptScore W2143448972C2780813555 @default.
- W2143448972 hasConceptScore W2143448972C2781356689 @default.