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• W2143451504 abstract "We adapted a minimal model to assess beta-cell function during a hyperglycemic glucose clamp and to uncover peculiar aspects of the relationship among beta-cell function, plasma glucose, and insulin sensitivity (IS) in offspring of Caucasian patients with type 2 diabetes (OfT2D). We pooled two data sets of OfT2D (n = 69) and control subjects (n = 45) with normal glucose regulation. Plasma C-peptide was measured during a hyperglycemic clamp ( approximately 10 mmol/l) to quantify model-based first-phase secretion and glucose sensitivity of second-phase secretion (beta). IS was quantified during the hyperglycemic clamp. In the pooled data, first-phase secretion was linearly and negatively related to fasting plasma glucose, but not IS; OfT2D lay on a distinct line shifted to the left of the control subjects. In contrast, beta was negatively related to IS, and OfT2D lay on a distinct line shifted more and more to the left of the control subjects, as IS was worse. Thus, in OfT2D lower beta-cell adaptive responses exist between ambient glycemia and first-phase insulin secretion and between IS and second-phase secretion. Under conditions leading to decreased insulin sensitivity, these disturbed relationships may lead to progression to diabetes in OfT2D." @default.
• W2143451504 created "2016-06-24" @default.
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• W2143451504 date "2003-02-01" @default.
• W2143451504 modified "2023-10-16" @default.
• W2143451504 title "Altered Homeostatic Adaptation of First- and Second-Phase β-Cell Secretion in the Offspring of Patients With Type 2 Diabetes" @default.
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• W2143451504 doi "https://doi.org/10.2337/diabetes.52.2.470" @default.
• W2143451504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12540623" @default.
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