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- W2143461736 abstract "The carbazole framework is found in many natural compounds of biological interest. Indolocarbazoles such as rebeccamycin and staurosporine which are either a topoisomerase I inhibitor (rebeccamycin) or a non selective kinase inhibitor (staurosporine) are bacterial metabolites. In the search for new antitumor agents, DNA damage checkpoint kinases, in particular Checkpoint kinase 1, have recently emerged as attractive targets for cancer therapy. This review reports the synthesis and Chk1 inhibitory activities of pyrrolocarbazole compounds bearing four or five fused rings. Keywords: Checkpoint kinase 1, antitumor agents, pyrrolocarbazole, granulatimide" @default.
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- W2143461736 date "2008-08-01" @default.
- W2143461736 modified "2023-10-18" @default.
- W2143461736 title "Pyrrolocarbazoles as Checkpoint 1 Kinase Inhibitors" @default.
- W2143461736 doi "https://doi.org/10.2174/187152008785133100" @default.
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