FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143496166> ?p ?o ?g. }

• W2143496166 endingPage "163" @default.
• W2143496166 startingPage "155" @default.
• W2143496166 abstract "Summary The interaction of K st R 2‐dependent promoters of the divergon constituted by the MSMEG _6000‐5999 and MSMEG _6001–6004 operons of Mycobacterium smegmatis which encode the genes involved in the lower cholesterol degradative pathway has been characterized. Footprint analyses have demonstrated experimentally for the first time that K st R 2 specifically binds to an operator region of 29 nucleotides containing the palindromic sequence AAGCAAGNNCTTGCTT . This region overlaps with the –10 and –35 boxes of the putative P 6000 and P 6001 divergent promoters, suggesting that K st R 2 represses their transcription by preventing the binding of the ribonucleic acid polymerase. A three‐dimensional model of the K st R 2 protein revealed a typical TetR ‐type regulator folding with two domains, a deoxyribonucleic acid ( DNA )‐binding N ‐terminal domain and a regulator‐binding C ‐terminal domain composed by three and six helices respectively. K st R 2 is an all alpha protein as confirmed by circular dichroism. We have determined that M . smegmatis is able to grow using sitolactone ( HIL ) as the only carbon source and that this compound induces the kst R 2 regulon in vivo . HIL or its open form 5 OH ‐ HIP were unable to release in vitro the K st R 2– DNA operator interaction, suggesting that 5 OH ‐ HIP ‐ C o A or a further derivative would induce the lower cholesterol catabolic pathway." @default.
• W2143496166 created "2016-06-24" @default.
• W2143496166 creator A5023127583 @default.
• W2143496166 creator A5030497528 @default.
• W2143496166 creator A5068081073 @default.
• W2143496166 creator A5068704164 @default.
• W2143496166 date "2015-02-01" @default.
• W2143496166 modified "2023-10-03" @default.
• W2143496166 title "Characterization of the KstR2 regulator responsible of the lower cholesterol degradative pathway in<i>M</i><i>ycobacterium smegmatis</i>" @default.
• W2143496166 cites W1816644759 @default.
• W2143496166 cites W1839665474 @default.
• W2143496166 cites W1932617301 @default.
• W2143496166 cites W1938275102 @default.
• W2143496166 cites W1942724014 @default.
• W2143496166 cites W1957134375 @default.
• W2143496166 cites W1967457339 @default.
• W2143496166 cites W1980933103 @default.
• W2143496166 cites W1987233255 @default.
• W2143496166 cites W1991067889 @default.
• W2143496166 cites W1991233072 @default.
• W2143496166 cites W1992595091 @default.
• W2143496166 cites W2007097682 @default.
• W2143496166 cites W2044498955 @default.
• W2143496166 cites W2046473371 @default.
• W2143496166 cites W2047841570 @default.
• W2143496166 cites W2051175773 @default.
• W2143496166 cites W2052902273 @default.
• W2143496166 cites W2056511259 @default.
• W2143496166 cites W2064846180 @default.
• W2143496166 cites W2074149880 @default.
• W2143496166 cites W2086780915 @default.
• W2143496166 cites W2086897743 @default.
• W2143496166 cites W2098975839 @default.
• W2143496166 cites W2107222513 @default.
• W2143496166 cites W2110344881 @default.
• W2143496166 cites W2113481444 @default.
• W2143496166 cites W2118940366 @default.
• W2143496166 cites W2128086899 @default.
• W2143496166 cites W2140354550 @default.
• W2143496166 cites W2141479656 @default.
• W2143496166 cites W2145268834 @default.
• W2143496166 cites W2152738897 @default.
• W2143496166 cites W2153514608 @default.
• W2143496166 cites W2161353001 @default.
• W2143496166 cites W2171535756 @default.
• W2143496166 cites W4254870115 @default.
• W2143496166 cites W659187498 @default.
• W2143496166 doi "https://doi.org/10.1111/1758-2229.12255" @default.
• W2143496166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25511435" @default.
• W2143496166 hasPublicationYear "2015" @default.
• W2143496166 type Work @default.
• W2143496166 sameAs 2143496166 @default.
• W2143496166 citedByCount "10" @default.
• W2143496166 countsByYear W21434961662016 @default.
• W2143496166 countsByYear W21434961662017 @default.
• W2143496166 countsByYear W21434961662018 @default.
• W2143496166 countsByYear W21434961662019 @default.
• W2143496166 countsByYear W21434961662021 @default.
• W2143496166 crossrefType "journal-article" @default.
• W2143496166 hasAuthorship W2143496166A5023127583 @default.
• W2143496166 hasAuthorship W2143496166A5030497528 @default.
• W2143496166 hasAuthorship W2143496166A5068081073 @default.
• W2143496166 hasAuthorship W2143496166A5068704164 @default.
• W2143496166 hasConcept C101762097 @default.
• W2143496166 hasConcept C104317684 @default.
• W2143496166 hasConcept C142724271 @default.
• W2143496166 hasConcept C143065580 @default.
• W2143496166 hasConcept C150194340 @default.
• W2143496166 hasConcept C153911025 @default.
• W2143496166 hasConcept C158448853 @default.
• W2143496166 hasConcept C185592680 @default.
• W2143496166 hasConcept C203075996 @default.
• W2143496166 hasConcept C2777204207 @default.
• W2143496166 hasConcept C2777975735 @default.
• W2143496166 hasConcept C2781069245 @default.
• W2143496166 hasConcept C552990157 @default.
• W2143496166 hasConcept C55493867 @default.
• W2143496166 hasConcept C6929976 @default.
• W2143496166 hasConcept C71240020 @default.
• W2143496166 hasConcept C71924100 @default.
• W2143496166 hasConcept C86339819 @default.
• W2143496166 hasConcept C86803240 @default.
• W2143496166 hasConceptScore W2143496166C101762097 @default.
• W2143496166 hasConceptScore W2143496166C104317684 @default.
• W2143496166 hasConceptScore W2143496166C142724271 @default.
• W2143496166 hasConceptScore W2143496166C143065580 @default.
• W2143496166 hasConceptScore W2143496166C150194340 @default.
• W2143496166 hasConceptScore W2143496166C153911025 @default.
• W2143496166 hasConceptScore W2143496166C158448853 @default.
• W2143496166 hasConceptScore W2143496166C185592680 @default.
• W2143496166 hasConceptScore W2143496166C203075996 @default.
• W2143496166 hasConceptScore W2143496166C2777204207 @default.
• W2143496166 hasConceptScore W2143496166C2777975735 @default.
• W2143496166 hasConceptScore W2143496166C2781069245 @default.
• W2143496166 hasConceptScore W2143496166C552990157 @default.
• W2143496166 hasConceptScore W2143496166C55493867 @default.
• W2143496166 hasConceptScore W2143496166C6929976 @default.
• W2143496166 hasConceptScore W2143496166C71240020 @default.

• next