FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143505655> ?p ?o ?g. }

• W2143505655 endingPage "159" @default.
• W2143505655 startingPage "151" @default.
• W2143505655 abstract "Summary Background: Aprotinin is a potent antifibrinolytic drug, which reduces postoperative bleeding and transfusion requirements. Recently, two observational studies reported increased incidence of renal dysfunction after aprotinin use in adults. Therefore, the aim of the study was to investigate the safety of aprotinin use in pediatric cardiac surgery patients. Methods: Data were prospectively and consecutively collected from 657 pediatric patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). The database was assessed with regard to a possible relationship between aprotinin administration and dialysis and between aprotinin and postoperative renal dysfunction [defined as 25% decrease in the creatinine clearance (Ccr) compared with the preoperative value] by propensity‐score adjustment and multivariable methods. Results: The incidence of dialysis (9.6% vs 4.1%; P = 0.005) and renal dysfunction (26.3% vs 16.1%; P = 0.019) was higher in patients who received aprotinin; however, propensity adjusted risk ratios were not significant [odds ratio (OR) of dialysis: 1.22; 95% confidence interval (CI) 0.46–3.22; OR of renal dysfunction 1.26; 95% CI: 0.66–1.92]. Aprotinin significantly reduced blood loss in the first postoperative 24 h. The main contributors of renal dysfunction were CPB duration, cumulative inotropic support, age, preoperative Ccr, amount of transfusion and pulmonary hypertension. Conclusions: Despite the higher incidences of renal dysfunction and failure in the aprotinin group, an independent role of the drug in the development of renal dysfunction or dialysis could not be demonstrated in pediatric cardiac patients undergoing CPB." @default.
• W2143505655 created "2016-06-24" @default.
• W2143505655 creator A5018247343 @default.
• W2143505655 creator A5023756614 @default.
• W2143505655 creator A5032003784 @default.
• W2143505655 creator A5034293942 @default.
• W2143505655 creator A5048195303 @default.
• W2143505655 creator A5053366391 @default.
• W2143505655 creator A5090310033 @default.
• W2143505655 date "2007-12-27" @default.
• W2143505655 modified "2023-10-14" @default.
• W2143505655 title "Aprotinin and renal dysfunction after pediatric cardiac surgery" @default.
• W2143505655 cites W128988202 @default.
• W2143505655 cites W1967171077 @default.
• W2143505655 cites W1973516067 @default.
• W2143505655 cites W1973914566 @default.
• W2143505655 cites W1978691495 @default.
• W2143505655 cites W1980679057 @default.
• W2143505655 cites W1984067267 @default.
• W2143505655 cites W1985106754 @default.
• W2143505655 cites W1992422541 @default.
• W2143505655 cites W1994142752 @default.
• W2143505655 cites W2001591759 @default.
• W2143505655 cites W2001747118 @default.
• W2143505655 cites W2003463282 @default.
• W2143505655 cites W2009699612 @default.
• W2143505655 cites W2013123055 @default.
• W2143505655 cites W2015547271 @default.
• W2143505655 cites W2055847168 @default.
• W2143505655 cites W2062576306 @default.
• W2143505655 cites W2062839391 @default.
• W2143505655 cites W2066135665 @default.
• W2143505655 cites W2068266143 @default.
• W2143505655 cites W2096459479 @default.
• W2143505655 cites W2116137344 @default.
• W2143505655 cites W2131852715 @default.
• W2143505655 cites W2133482423 @default.
• W2143505655 cites W2136618708 @default.
• W2143505655 cites W2138373808 @default.
• W2143505655 cites W2141900287 @default.
• W2143505655 cites W2144358802 @default.
• W2143505655 cites W2157206570 @default.
• W2143505655 cites W3000453819 @default.
• W2143505655 cites W4377086258 @default.
• W2143505655 doi "https://doi.org/10.1111/j.1460-9592.2007.02398.x" @default.
• W2143505655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18184247" @default.
• W2143505655 hasPublicationYear "2007" @default.
• W2143505655 type Work @default.
• W2143505655 sameAs 2143505655 @default.
• W2143505655 citedByCount "35" @default.
• W2143505655 countsByYear W21435056552012 @default.
• W2143505655 countsByYear W21435056552013 @default.
• W2143505655 countsByYear W21435056552015 @default.
• W2143505655 countsByYear W21435056552017 @default.
• W2143505655 countsByYear W21435056552021 @default.
• W2143505655 countsByYear W21435056552022 @default.
• W2143505655 crossrefType "journal-article" @default.
• W2143505655 hasAuthorship W2143505655A5018247343 @default.
• W2143505655 hasAuthorship W2143505655A5023756614 @default.
• W2143505655 hasAuthorship W2143505655A5032003784 @default.
• W2143505655 hasAuthorship W2143505655A5034293942 @default.
• W2143505655 hasAuthorship W2143505655A5048195303 @default.
• W2143505655 hasAuthorship W2143505655A5053366391 @default.
• W2143505655 hasAuthorship W2143505655A5090310033 @default.
• W2143505655 hasConcept C126322002 @default.
• W2143505655 hasConcept C141071460 @default.
• W2143505655 hasConcept C156957248 @default.
• W2143505655 hasConcept C159641895 @default.
• W2143505655 hasConcept C2778789114 @default.
• W2143505655 hasConcept C2778881276 @default.
• W2143505655 hasConcept C2779637338 @default.
• W2143505655 hasConcept C2779978075 @default.
• W2143505655 hasConcept C2780799893 @default.
• W2143505655 hasConcept C2781436528 @default.
• W2143505655 hasConcept C2991743468 @default.
• W2143505655 hasConcept C42219234 @default.
• W2143505655 hasConcept C71924100 @default.
• W2143505655 hasConceptScore W2143505655C126322002 @default.
• W2143505655 hasConceptScore W2143505655C141071460 @default.
• W2143505655 hasConceptScore W2143505655C156957248 @default.
• W2143505655 hasConceptScore W2143505655C159641895 @default.
• W2143505655 hasConceptScore W2143505655C2778789114 @default.
• W2143505655 hasConceptScore W2143505655C2778881276 @default.
• W2143505655 hasConceptScore W2143505655C2779637338 @default.
• W2143505655 hasConceptScore W2143505655C2779978075 @default.
• W2143505655 hasConceptScore W2143505655C2780799893 @default.
• W2143505655 hasConceptScore W2143505655C2781436528 @default.
• W2143505655 hasConceptScore W2143505655C2991743468 @default.
• W2143505655 hasConceptScore W2143505655C42219234 @default.
• W2143505655 hasConceptScore W2143505655C71924100 @default.
• W2143505655 hasIssue "2" @default.
• W2143505655 hasLocation W21435056551 @default.
• W2143505655 hasLocation W21435056552 @default.
• W2143505655 hasOpenAccess W2143505655 @default.
• W2143505655 hasPrimaryLocation W21435056551 @default.
• W2143505655 hasRelatedWork W2011667032 @default.
• W2143505655 hasRelatedWork W2011964132 @default.
• W2143505655 hasRelatedWork W2042395242 @default.

• next