FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143506710> ?p ?o ?g. }

• W2143506710 endingPage "571" @default.
• W2143506710 startingPage "563" @default.
• W2143506710 abstract "The status of Cr(III) as an essential micronutrient for humans is currently under question. No functional Cr(III)-containing biomolecules have been definitively described as yet, and accumulated experience in the use of Cr(III) nutritional supplements (such as [Cr(pic) 3], where pic = 2-pyridinecarboxylato) has shown no measurable benefits for nondiabetic people. Although the use of large doses of Cr(III) supplements may lead to improvements in glucose metabolism for type 2 diabetics, there is a growing concern over the possible genotoxicity of these compounds, particularly of [Cr(pic) 3]. The current perspective discusses chemical transformations of Cr(III) nutritional supplements in biological media, with implications for both beneficial and toxic actions of Cr(III) complexes, which are likely to arise from the same biochemical mechanisms, dependent on concentrations of the reactive species. These species include: (i) partial hydrolysis products of Cr(III) nutritional supplements, which are capable of binding to biological macromolecules and altering their functions; and (ii) highly reactive Cr(VI/V/IV) species and organic radicals, formed in reactions of Cr(III) with biological oxidants. Low concentrations of these species are likely to cause alterations in cell signaling (including enhancement of insulin signaling) through interactions with the active centers of regulatory enzymes in the cell membrane or in the cytoplasm, while higher concentrations are likely to produce genotoxic DNA lesions in the cell nucleus. These data suggest that the potential for genotoxic side-effects of Cr(III) complexes may outweigh their possible benefits as insulin enhancers, and that recommendations for their use as either nutritional supplements or antidiabetic drugs need to be reconsidered in light of these recent findings." @default.
• W2143506710 created "2016-06-24" @default.
• W2143506710 creator A5040829028 @default.
• W2143506710 creator A5049127992 @default.
• W2143506710 date "2008-02-01" @default.
• W2143506710 modified "2023-10-02" @default.
• W2143506710 title "Chemical Properties and Toxicity of Chromium(III) Nutritional Supplements" @default.
• W2143506710 cites W1242826577 @default.
• W2143506710 cites W127300997 @default.
• W2143506710 cites W134117404 @default.
• W2143506710 cites W1523007277 @default.
• W2143506710 cites W1605619295 @default.
• W2143506710 cites W1608565424 @default.
• W2143506710 cites W164268904 @default.
• W2143506710 cites W1964070264 @default.
• W2143506710 cites W1967307894 @default.
• W2143506710 cites W1972656394 @default.
• W2143506710 cites W1978929205 @default.
• W2143506710 cites W1982453977 @default.
• W2143506710 cites W1984559709 @default.
• W2143506710 cites W1985326582 @default.
• W2143506710 cites W1994870367 @default.
• W2143506710 cites W1998286386 @default.
• W2143506710 cites W199901768 @default.
• W2143506710 cites W2007562971 @default.
• W2143506710 cites W2008270743 @default.
• W2143506710 cites W2009923409 @default.
• W2143506710 cites W2010361499 @default.
• W2143506710 cites W2010896197 @default.
• W2143506710 cites W2013209831 @default.
• W2143506710 cites W2013988037 @default.
• W2143506710 cites W2018634659 @default.
• W2143506710 cites W2018739369 @default.
• W2143506710 cites W2021222537 @default.
• W2143506710 cites W2023177154 @default.
• W2143506710 cites W2023873099 @default.
• W2143506710 cites W2024681988 @default.
• W2143506710 cites W2026842853 @default.
• W2143506710 cites W2030002653 @default.
• W2143506710 cites W2030154800 @default.
• W2143506710 cites W2030712707 @default.
• W2143506710 cites W2034915767 @default.
• W2143506710 cites W2036663694 @default.
• W2143506710 cites W2039085439 @default.
• W2143506710 cites W2040956844 @default.
• W2143506710 cites W2042637210 @default.
• W2143506710 cites W2045984379 @default.
• W2143506710 cites W2045996177 @default.
• W2143506710 cites W2047084762 @default.
• W2143506710 cites W2051580821 @default.
• W2143506710 cites W2052326460 @default.
• W2143506710 cites W2053430176 @default.
• W2143506710 cites W2056445092 @default.
• W2143506710 cites W2056786347 @default.
• W2143506710 cites W2057329144 @default.
• W2143506710 cites W2057655951 @default.
• W2143506710 cites W2059739241 @default.
• W2143506710 cites W2061782099 @default.
• W2143506710 cites W2063675513 @default.
• W2143506710 cites W2065115448 @default.
• W2143506710 cites W2066431484 @default.
• W2143506710 cites W2066868909 @default.
• W2143506710 cites W2067597129 @default.
• W2143506710 cites W2068434973 @default.
• W2143506710 cites W2070707407 @default.
• W2143506710 cites W2076940285 @default.
• W2143506710 cites W2078998726 @default.
• W2143506710 cites W2080239094 @default.
• W2143506710 cites W2086344218 @default.
• W2143506710 cites W2088517647 @default.
• W2143506710 cites W2090345738 @default.
• W2143506710 cites W2090832700 @default.
• W2143506710 cites W2093275093 @default.
• W2143506710 cites W2093374393 @default.
• W2143506710 cites W2095318039 @default.
• W2143506710 cites W2097977544 @default.
• W2143506710 cites W2104246375 @default.
• W2143506710 cites W2105905118 @default.
• W2143506710 cites W2108983113 @default.
• W2143506710 cites W2112301315 @default.
• W2143506710 cites W2132322696 @default.
• W2143506710 cites W2134552785 @default.
• W2143506710 cites W2146116042 @default.
• W2143506710 cites W2152656461 @default.
• W2143506710 cites W2153411398 @default.
• W2143506710 cites W2154382681 @default.
• W2143506710 cites W2155743140 @default.
• W2143506710 cites W2156518231 @default.
• W2143506710 cites W2160439881 @default.
• W2143506710 cites W2168774616 @default.
• W2143506710 cites W2216647381 @default.
• W2143506710 cites W2481792730 @default.
• W2143506710 cites W2489463306 @default.
• W2143506710 cites W2496680844 @default.
• W2143506710 cites W32236186 @default.
• W2143506710 cites W4291395926 @default.
• W2143506710 cites W46617929 @default.
• W2143506710 cites W5112478 @default.

• next