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- W2143516276 endingPage "34" @default.
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- W2143516276 abstract "Microbial infection initiates complex interactions between the pathogen and the host. Pathogens express several signature molecules, known as pathogen-associated molecular patterns (PAMPs), which are essential for survival and pathogenicity. PAMPs are sensed by evolutionarily conserved, germline-encoded host sensors known as pathogen recognition receptors (PRRs). Recognition of PAMPs by PRRs rapidly triggers an array of anti-microbial immune responses through the induction of various inflammatory cytokines, chemokines and type I interferons. These responses also initiate the development of pathogen-specific, long-lasting adaptive immunity through B and T lymphocytes. Several families of PRRs, including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs), and DNA receptors (cytosolic sensors for DNA), are known to play a crucial role in host defense. In this review, we comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated by PRRs." @default.
- W2143516276 created "2016-06-24" @default.
- W2143516276 creator A5013773246 @default.
- W2143516276 creator A5018553332 @default.
- W2143516276 creator A5062825404 @default.
- W2143516276 date "2011-01-01" @default.
- W2143516276 modified "2023-10-14" @default.
- W2143516276 title "Pathogen Recognition by the Innate Immune System" @default.
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