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• W2143522905 endingPage "2307" @default.
• W2143522905 startingPage "2300" @default.
• W2143522905 abstract "ABSTRACT The nuclear factor of activated T cells (NFAT) transcription factor is implicated in expression of the cytokine interleukin-2 (IL-2). Binding sites for NFAT are located in the IL-2 promoter. Furthermore, pharmacological studies demonstrate that the drug cyclosporin A inhibits both NFAT activation and IL-2 expression. However, targeted disruption of the NFAT1 and NFAT2 genes in mice does not cause decreased IL-2 secretion. The role of NFAT in IL-2 gene expression is therefore unclear. Here we report the construction of a dominant-negative NFAT mutant (dnNFAT) that selectively inhibits NFAT-mediated gene expression. The inhibitory effect of dnNFAT is mediated by suppression of activation-induced nuclear translocation of NFAT. Expression of dnNFAT in cultured T cells caused inhibition of IL-2 promoter activity and decreased expression of IL-2 protein. Similarly, expression of dnNFAT in transgenic mice also caused decreased IL-2 gene expression. These data demonstrate that NFAT is a critical component of the signaling pathway that regulates IL-2 expression." @default.
• W2143522905 created "2016-06-24" @default.
• W2143522905 creator A5028742170 @default.
• W2143522905 creator A5049868751 @default.
• W2143522905 creator A5051208328 @default.
• W2143522905 date "1999-03-01" @default.
• W2143522905 modified "2023-10-12" @default.
• W2143522905 title "Requirement for Transcription Factor NFAT in Interleukin-2 Expression" @default.
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• W2143522905 doi "https://doi.org/10.1128/mcb.19.3.2300" @default.
• W2143522905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/84022" @default.
• W2143522905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10022916" @default.
• W2143522905 hasPublicationYear "1999" @default.
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