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- W2143574556 abstract "Thymosin alpha-1 (T alpha 1) significantly enhances the fertilizability of sperm from fertile men by increasing capacitation and/or acrosome reaction. The present study was conducted to investigate the effect of T alpha 1 on fertilizing capacity of sperm of infertile men using the sperm penetration assay (SPA) in a multicenter clinical trial. T alpha 1 significantly (p = .0006 to < .0001) increased (31 to 45%) fertilizing capacity of sperm of 76% (50/68) of infertile men as defined by the sperm penetration index in SPA. The enhancing effect of T alpha 1 and the degree of enhancement depended on the T alpha 1 concentration in the seminal plasma, since these parameters showed a significant intercorrelation (r = .65 to .74, p = .039 to .01). It would appear that T alpha 1 may have clinical application in the diagnosis and treatment of male infertility especially mediated through defective sperm function." @default.
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- W2143574556 date "1995-01-01" @default.
- W2143574556 modified "2023-09-24" @default.
- W2143574556 title "Treatment with Thymosin Alpha-1 Increases Fertilizing Capacity of Sperm of Infertile Men: A Multicenter Trial" @default.
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- W2143574556 doi "https://doi.org/10.3109/01485019508987866" @default.
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