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- W2143596592 endingPage "e2010023" @default.
- W2143596592 startingPage "e2010023" @default.
- W2143596592 abstract "The aim of this review is to summarize the contribution of platelets and leukocytes and their interactions in inflammation and blood coagulation and its possible relevance in the pathogenesis of thrombosis. There is some evidence of an association between infection/inflammation and thrombosis. This is likely a bidirectional relationship. The presence of a thrombus may serve as a nidus of infection. Vascular injury indeed promotes platelet and leukocyte activation and thrombus formation and the thrombus and its components facilitate adherence of bacteria to the vessel wall. Alternatively, an infection and the associated inflammation can trigger platelet and leukocyte activation and thrombus formation. In either case platelets and leukocytes co-localize and interact in the area of vascular injury, at sites of inflammation and/or at sites of thrombosis. Following vascular injury, the subendothelial tissue, a thrombogenic surface, becomes available for interaction with these blood cells. Tissue factor, found not only in media and adventitia of the vascular wall, but also on activated platelets and leukocytes, triggers blood coagulation. Vascular-blood cell interactions, mediated by the release of preformed components of the endothelium, is modulated by both cell adhesion and production of soluble stimulatory or inhibitory molecules that alter cell function: adhesion molecules regulate cell-cell contact and facilitate the modulation of biochemical pathways relevant to inflammatory and/or thrombotic processes." @default.
- W2143596592 created "2016-06-24" @default.
- W2143596592 creator A5033092400 @default.
- W2143596592 creator A5041057292 @default.
- W2143596592 creator A5089109611 @default.
- W2143596592 date "2010-08-06" @default.
- W2143596592 modified "2023-10-12" @default.
- W2143596592 title "PLATELET-LEUKOCYTE INTERACTIONS : MULTIPLE LINKS BETWEEN INFLAMMATION , BLOOD COAGULATION AND VASCULAR RISK" @default.
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- W2143596592 doi "https://doi.org/10.4084/mjhid.2010.023" @default.
- W2143596592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3033146" @default.
- W2143596592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21415976" @default.
- W2143596592 hasPublicationYear "2010" @default.