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• W2143598845 startingPage "1240" @default.
• W2143598845 abstract "<b><i>Objective:</i></b> To evaluate neurologic complications in patients with immune-mediated heparin-induced thrombocytopenia (HIT) with respect to incidence, clinical characteristics, outcome, and therapy. <b><i>Methods:</i></b> One hundred and twenty consecutive patients with immune-mediated HIT were recruited over a period of 11 years and studied retrospectively for the occurrence of neurologic complications. Diagnosis of HIT was based on established clinical criteria and confirmed by detection of heparin-induced antibodies using functional and immunologic tests. <b><i>Results:</i></b> Eleven of the 120 patients (9.2%) presented with neurologic complications; 7 suffered from ischemic cerebrovascular events, 3 from cerebral venous thrombosis, and 1 had a transient confusional state during high-dose heparin administration. Primary intracerebral hemorrhage was not observed. The relative mortality was much higher (Chi-square test, <i>p</i> < 0.01) in HIT patients with neurologic complications (55%) as compared to patients without neurologic complications (11%). The mean platelet count nadir in neurologic patients was 38 ± 25 × 10⁹/l on average, and was lower in patients with fatal outcome compared to those who survived (21 ± 13 × 10⁹/l versus 58 ± 21 × 10⁹/l; <i>p</i> < 0.05, Wilcoxon test). In three patients neurologic complications preceded thrombocytopenia. There was a high coincidence of HIT-associated neurologic complications with other HIT-associated arterial or venous thrombotic manifestations. <b><i>Conclusion:</i></b> Neurologic complications in HIT are relatively rare, but associated with a high comorbidity and mortality. HIT-associated neurologic complications include cerebrovascular ischemia and cerebral venous thrombosis. They may occur at a normal platelet count." @default.
• W2143598845 created "2016-06-24" @default.
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• W2143598845 date "2000-03-28" @default.
• W2143598845 modified "2023-09-30" @default.
• W2143598845 title "Neurologic complications in immune-mediated heparin-induced thrombocytopenia" @default.
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• W2143598845 doi "https://doi.org/10.1212/wnl.54.6.1240" @default.
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