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- W2143609452 abstract "The intracellular pathogen Mycobacterium tuberculosis (Mtb) is exposed to multiple host antimicrobial pathways, including toxic gases such as superoxide, nitric oxide and carbon monoxide (CO). To survive, mycobacteria evolved mechanisms to resist the toxic environment, and in this review we focus on a relatively new field, namely, the role of macrophage heme oxygenase and its enzymatic product CO in Mtb pathogenesis. In particular, we focus on (i) the induction of heme oxygenase during Mtb infection and its relevance to Mtb pathogenesis, (ii) the ability of mycobacteria to catabolize CO, (iii) the transcriptional reprogramming of Mtb by exposure to CO, (iv) the general antimicrobial properties of CO and (v) new genetic evidence characterizing the ability of Mtb to resist CO toxicity. Developing a complete molecular and genetic understanding of the pathogenesis of Mtb is essential to its eventual eradication." @default.
- W2143609452 created "2016-06-24" @default.
- W2143609452 creator A5055178190 @default.
- W2143609452 creator A5063113744 @default.
- W2143609452 date "2012-01-01" @default.
- W2143609452 modified "2023-09-27" @default.
- W2143609452 title "Effect of carbon monoxide on Mycobacterium tuberculosis pathogenesis" @default.
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- W2143609452 doi "https://doi.org/10.1186/2045-9912-2-30" @default.
- W2143609452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3537638" @default.
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