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• W2143629997 abstract "Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. The interference complex of the type III-A CRISPR-Cas system is composed of five Cas proteins (Csm1-Csm5) and a crRNA, and targets invading DNA. Here, we show that the Csm1, Csm3, and Csm4 proteins from Methanocaldococcus jannaschii form a stable subcomplex. We also report the crystal structure of the M. jannaschii Csm3-Csm4 subcomplex at 3.1Å resolution. The complex structure revealed the presence of a basic concave surface around their interface, suggesting the RNA and/or DNA binding ability of the complex. A gel retardation analysis showed that the Csm3-Csm4 complex binds single-stranded RNA in a non-sequence-specific manner. Csm4 structurally resembles Cmr3, a component of the type III-B CRISPR-Cas interference complex. Based on bioinformatics, we constructed a model structure of the Csm1-Csm4-Csm3 ternary complex, which provides insights into its role in the Csm interference complex." @default.
• W2143629997 created "2016-06-24" @default.
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• W2143629997 date "2015-01-01" @default.
• W2143629997 modified "2023-09-24" @default.
• W2143629997 title "Crystal Structure of the Csm3–Csm4 Subcomplex in the Type III-A CRISPR–Cas Interference Complex" @default.
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• W2143629997 doi "https://doi.org/10.1016/j.jmb.2014.09.029" @default.
• W2143629997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25451598" @default.
• W2143629997 hasPublicationYear "2015" @default.
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