Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143641337> ?p ?o ?g. }
- W2143641337 endingPage "44" @default.
- W2143641337 startingPage "35" @default.
- W2143641337 abstract "Cancer is a heterogeneous disease and consequently an exact diagnosis is as important as the actual therapy. Therefore, identification of novel diagnostic biomarker targets is urgently needed. Physiological and pathological changes are reflected by post-translational modifications of proteins. Each post-translational modification (e.g., proteolytic cleavage) is the result of a specific local process and may produce disease-specific neoepitopes. Neoepitopes have been successfully used as biomarkers in many diseases, and may also serve as promising tools in the development of future diagnostic assays within oncology. By specifically targeting neoepitopes, more information regarding disease-type and -state may be obtained and future research into neoepitopes will provide important and novel means for the diagnosis, prognosis and treatment efficacy in cancer. In this paper, we focus on protein ectodomain shedding and the generation of neoepitopes as future noninvasive (serological) cancer biomarkers. We use the protein ectodomain shedding of the human epidermal growth factor receptor 2, which is associated with breast cancer, as an example. We assess the current status of measuring human epidermal growth factor receptor 2 and discuss how this potentially could be improved. Furthermore, we expand the discussion to include examples of other cancer associated proteins." @default.
- W2143641337 created "2016-06-24" @default.
- W2143641337 creator A5006255197 @default.
- W2143641337 creator A5010862898 @default.
- W2143641337 creator A5016021368 @default.
- W2143641337 creator A5027349510 @default.
- W2143641337 creator A5049099295 @default.
- W2143641337 creator A5062465642 @default.
- W2143641337 date "2013-01-01" @default.
- W2143641337 modified "2023-10-17" @default.
- W2143641337 title "Bringing cancer serological diagnosis to a new level: focusing on HER2, protein ectodomain shedding and neoepitope technology" @default.
- W2143641337 cites W1599285204 @default.
- W2143641337 cites W1849285658 @default.
- W2143641337 cites W1893181623 @default.
- W2143641337 cites W1955382134 @default.
- W2143641337 cites W1968782748 @default.
- W2143641337 cites W1970458434 @default.
- W2143641337 cites W1973033337 @default.
- W2143641337 cites W1982917143 @default.
- W2143641337 cites W1983930854 @default.
- W2143641337 cites W1987881959 @default.
- W2143641337 cites W1993169666 @default.
- W2143641337 cites W1997104566 @default.
- W2143641337 cites W2000493585 @default.
- W2143641337 cites W2002907282 @default.
- W2143641337 cites W2003500892 @default.
- W2143641337 cites W2007744599 @default.
- W2143641337 cites W2009929157 @default.
- W2143641337 cites W2012104993 @default.
- W2143641337 cites W2013084840 @default.
- W2143641337 cites W2014053430 @default.
- W2143641337 cites W2014603723 @default.
- W2143641337 cites W2024729393 @default.
- W2143641337 cites W2032592862 @default.
- W2143641337 cites W2035332337 @default.
- W2143641337 cites W2038964728 @default.
- W2143641337 cites W2046246972 @default.
- W2143641337 cites W2049535884 @default.
- W2143641337 cites W2054430764 @default.
- W2143641337 cites W2056362028 @default.
- W2143641337 cites W2056761337 @default.
- W2143641337 cites W2056875960 @default.
- W2143641337 cites W2057502240 @default.
- W2143641337 cites W2069533740 @default.
- W2143641337 cites W2079095545 @default.
- W2143641337 cites W2079441054 @default.
- W2143641337 cites W2079911937 @default.
- W2143641337 cites W2080737967 @default.
- W2143641337 cites W2085324134 @default.
- W2143641337 cites W2091242368 @default.
- W2143641337 cites W2095156669 @default.
- W2143641337 cites W2097849390 @default.
- W2143641337 cites W2113868669 @default.
- W2143641337 cites W2115330997 @default.
- W2143641337 cites W2117198913 @default.
- W2143641337 cites W2126415088 @default.
- W2143641337 cites W2130900820 @default.
- W2143641337 cites W2132105964 @default.
- W2143641337 cites W2134473118 @default.
- W2143641337 cites W2137399990 @default.
- W2143641337 cites W2137668465 @default.
- W2143641337 cites W2138501293 @default.
- W2143641337 cites W2141393790 @default.
- W2143641337 cites W2143241095 @default.
- W2143641337 cites W2153830154 @default.
- W2143641337 cites W2154277980 @default.
- W2143641337 cites W2155788180 @default.
- W2143641337 cites W2156677665 @default.
- W2143641337 cites W2165283019 @default.
- W2143641337 cites W2166084034 @default.
- W2143641337 cites W2169052701 @default.
- W2143641337 cites W4236101613 @default.
- W2143641337 cites W4249938255 @default.
- W2143641337 cites W59864822 @default.
- W2143641337 doi "https://doi.org/10.2217/fon.12.161" @default.
- W2143641337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23252562" @default.
- W2143641337 hasPublicationYear "2013" @default.
- W2143641337 type Work @default.
- W2143641337 sameAs 2143641337 @default.
- W2143641337 citedByCount "7" @default.
- W2143641337 countsByYear W21436413372013 @default.
- W2143641337 countsByYear W21436413372018 @default.
- W2143641337 countsByYear W21436413372019 @default.
- W2143641337 countsByYear W21436413372020 @default.
- W2143641337 countsByYear W21436413372021 @default.
- W2143641337 countsByYear W21436413372023 @default.
- W2143641337 crossrefType "journal-article" @default.
- W2143641337 hasAuthorship W2143641337A5006255197 @default.
- W2143641337 hasAuthorship W2143641337A5010862898 @default.
- W2143641337 hasAuthorship W2143641337A5016021368 @default.
- W2143641337 hasAuthorship W2143641337A5027349510 @default.
- W2143641337 hasAuthorship W2143641337A5049099295 @default.
- W2143641337 hasAuthorship W2143641337A5062465642 @default.
- W2143641337 hasConcept C1009742 @default.
- W2143641337 hasConcept C121608353 @default.
- W2143641337 hasConcept C126322002 @default.
- W2143641337 hasConcept C142724271 @default.
- W2143641337 hasConcept C170493617 @default.