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- W2143655767 endingPage "20150589" @default.
- W2143655767 startingPage "20150589" @default.
- W2143655767 abstract "Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and extracellular matrix of all multicellular animals, whereas heparin is present within mast cells and can be viewed as a more sulfated, tissue-specific, HS variant. HS and heparin regulate biological processes through interactions with a large repertoire of proteins. Owing to these interactions and diverse effects observed during in vitro, ex vivo and in vivo experiments, manifold biological/pharmacological activities have been attributed to them. The properties that have been thought to bestow protein binding and biological activity upon HS and heparin vary from high levels of sequence specificity to a dependence on charge. In contrast to these opposing opinions, we will argue that the evidence supports both a level of redundancy and a degree of selectivity in the structure-activity relationship. The relationship between this apparent redundancy, the multi-dentate nature of heparin and HS polysaccharide chains, their involvement in protein networks and the multiple binding sites on proteins, each possessing different properties, will also be considered. Finally, the role of cations in modulating HS/heparin activity will be reviewed and some of the implications for structure-activity relationships and regulation will be discussed." @default.
- W2143655767 created "2016-06-24" @default.
- W2143655767 creator A5020871383 @default.
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- W2143655767 creator A5069868342 @default.
- W2143655767 creator A5074935517 @default.
- W2143655767 creator A5087235862 @default.
- W2143655767 date "2015-09-01" @default.
- W2143655767 modified "2023-10-16" @default.
- W2143655767 title "Heparan sulfate and heparin interactions with proteins" @default.
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