FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143662443> ?p ?o ?g. }

• W2143662443 endingPage "1451" @default.
• W2143662443 startingPage "1447" @default.
• W2143662443 abstract "Increasing antibiotic resistance in the enterococci, including the capacity for beta-lactamase production and the development of high-level aminoglycoside resistance, has complicated the treatment of serious enterococcal infections, which often require synergistic antibiotic combinations for cure. We utilized the rabbit model of aortic valve endocarditis to investigate the effects of various antibiotics, alone and in combination, against a multiply antibiotic-resistant isolate of Enterococcus faecalis. Female New Zealand White rabbits were infected with either a beta-lactamase-producing, gentamicin-resistant isolate of E. faecalis or a non-beta-lactamase-producing, aminoglycoside-susceptible isolate, and the mean log10 CFU per gram of vegetation were determined. The most active agents were low-dose ampicillin-sulbactam (200 mg/kg of body weight per day), high-dose ampicillin-sulbactam (400 mg/kg of body weight per day), and vancomycin (150 mg/kg of body weight per day), which reduced the titers of bacteria by 2.27, 2.76, and 2.85 log10 (CFU/g, respectively, compared with controls. While ampicillin-sulbactam and vancomycin were equally efficacious in reducing titers of bacteria in vegetations, no animals were cured (defined as < 2 log10 CFU/g of vegetation) by either agent, whether treatment was continued for 3 or 7 days. The addition of gentamicin was not associated with increased killing in rabbits infected with the aminoglycoside-resistant isolate. Both high-dose ampicillin-sulbactam and vancomycin regimens demonstrated significant, continued reduction in bacterial titers with the longer periods of treatment (P < or = 0.05); 7-day treatment with high-dose ampicillin-sulbactam produced a greater reduction in bacterial titers in vegetation than 7-day treatment with vancomycin (P < or = 0.05). We conclude that ampicillin-sulbactam and vancomycin are equally effective in the treatment of experimental endocarditis due to beta-lactamase-producing, highly gentamicin-resistant E. faecalis. The optimum therapy for such infections in humans is not known." @default.
• W2143662443 created "2016-06-24" @default.
• W2143662443 creator A5037974063 @default.
• W2143662443 creator A5046489335 @default.
• W2143662443 creator A5053313608 @default.
• W2143662443 creator A5060111613 @default.
• W2143662443 creator A5064136295 @default.
• W2143662443 date "1993-07-01" @default.
• W2143662443 modified "2023-09-25" @default.
• W2143662443 title "Comparison of ampicillin-sulbactam with vancomycin for treatment of experimental endocarditis due to a beta-lactamase-producing, highly gentamicin-resistant isolate of Enterococcus faecalis" @default.
• W2143662443 cites W1966464189 @default.
• W2143662443 cites W1980187934 @default.
• W2143662443 cites W1986207892 @default.
• W2143662443 cites W2008920329 @default.
• W2143662443 cites W2015636782 @default.
• W2143662443 cites W2033179960 @default.
• W2143662443 cites W2048101866 @default.
• W2143662443 cites W2049257474 @default.
• W2143662443 cites W2056680045 @default.
• W2143662443 cites W2067789217 @default.
• W2143662443 cites W2079184155 @default.
• W2143662443 cites W2108262847 @default.
• W2143662443 cites W2131847667 @default.
• W2143662443 cites W2147321906 @default.
• W2143662443 cites W2164997544 @default.
• W2143662443 cites W2169620427 @default.
• W2143662443 cites W2312767348 @default.
• W2143662443 cites W2315940187 @default.
• W2143662443 cites W2318268472 @default.
• W2143662443 cites W2333986914 @default.
• W2143662443 cites W2335460732 @default.
• W2143662443 cites W4255074921 @default.
• W2143662443 doi "https://doi.org/10.1128/aac.37.7.1447" @default.
• W2143662443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/187992" @default.
• W2143662443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8363374" @default.
• W2143662443 hasPublicationYear "1993" @default.
• W2143662443 type Work @default.
• W2143662443 sameAs 2143662443 @default.
• W2143662443 citedByCount "17" @default.
• W2143662443 countsByYear W21436624432015 @default.
• W2143662443 countsByYear W21436624432016 @default.
• W2143662443 countsByYear W21436624432017 @default.
• W2143662443 countsByYear W21436624432018 @default.
• W2143662443 countsByYear W21436624432020 @default.
• W2143662443 crossrefType "journal-article" @default.
• W2143662443 hasAuthorship W2143662443A5037974063 @default.
• W2143662443 hasAuthorship W2143662443A5046489335 @default.
• W2143662443 hasAuthorship W2143662443A5053313608 @default.
• W2143662443 hasAuthorship W2143662443A5060111613 @default.
• W2143662443 hasAuthorship W2143662443A5064136295 @default.
• W2143662443 hasBestOaLocation W21436624432 @default.
• W2143662443 hasConcept C126322002 @default.
• W2143662443 hasConcept C2775832221 @default.
• W2143662443 hasConcept C2775872228 @default.
• W2143662443 hasConcept C2776021129 @default.
• W2143662443 hasConcept C2777787772 @default.
• W2143662443 hasConcept C2778478555 @default.
• W2143662443 hasConcept C2778980435 @default.
• W2143662443 hasConcept C2779489039 @default.
• W2143662443 hasConcept C2779631663 @default.
• W2143662443 hasConcept C2779895986 @default.
• W2143662443 hasConcept C2780585763 @default.
• W2143662443 hasConcept C501593827 @default.
• W2143662443 hasConcept C523546767 @default.
• W2143662443 hasConcept C54355233 @default.
• W2143662443 hasConcept C71924100 @default.
• W2143662443 hasConcept C86803240 @default.
• W2143662443 hasConcept C89423630 @default.
• W2143662443 hasConcept C94665300 @default.
• W2143662443 hasConceptScore W2143662443C126322002 @default.
• W2143662443 hasConceptScore W2143662443C2775832221 @default.
• W2143662443 hasConceptScore W2143662443C2775872228 @default.
• W2143662443 hasConceptScore W2143662443C2776021129 @default.
• W2143662443 hasConceptScore W2143662443C2777787772 @default.
• W2143662443 hasConceptScore W2143662443C2778478555 @default.
• W2143662443 hasConceptScore W2143662443C2778980435 @default.
• W2143662443 hasConceptScore W2143662443C2779489039 @default.
• W2143662443 hasConceptScore W2143662443C2779631663 @default.
• W2143662443 hasConceptScore W2143662443C2779895986 @default.
• W2143662443 hasConceptScore W2143662443C2780585763 @default.
• W2143662443 hasConceptScore W2143662443C501593827 @default.
• W2143662443 hasConceptScore W2143662443C523546767 @default.
• W2143662443 hasConceptScore W2143662443C54355233 @default.
• W2143662443 hasConceptScore W2143662443C71924100 @default.
• W2143662443 hasConceptScore W2143662443C86803240 @default.
• W2143662443 hasConceptScore W2143662443C89423630 @default.
• W2143662443 hasConceptScore W2143662443C94665300 @default.
• W2143662443 hasIssue "7" @default.
• W2143662443 hasLocation W21436624431 @default.
• W2143662443 hasLocation W21436624432 @default.
• W2143662443 hasLocation W21436624433 @default.
• W2143662443 hasOpenAccess W2143662443 @default.
• W2143662443 hasPrimaryLocation W21436624431 @default.
• W2143662443 hasRelatedWork W1980029369 @default.
• W2143662443 hasRelatedWork W2030518753 @default.
• W2143662443 hasRelatedWork W2040067636 @default.
• W2143662443 hasRelatedWork W2044721983 @default.
• W2143662443 hasRelatedWork W2088960117 @default.

• next