FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143664312> ?p ?o ?g. }

• W2143664312 endingPage "71" @default.
• W2143664312 startingPage "64" @default.
• W2143664312 abstract "Alterations in the function of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) have been observed in both in vivo and in vitro models of epileptogenesis; however the molecular mechanism mediating the effects of epileptogenesis on CaM kinase II has not been elucidated. This study was initiated to evaluate the molecular pathways involved in causing the long-lasting decrease in CaM kinase II activity in the hippocampal neuronal culture model of low Mg2+-induced spontaneous recurrent epileptiform discharges (SREDs). We show here that the decrease in CaM kinase II activity associated with SREDs in hippocampal cultures involves a Ca2+/N-methyl-d-aspartate (NMDA) receptor-dependent mechanism. Low Mg2+-induced SREDs result in a significant decrease in Ca2+/calmodulin-dependent substrate phosphorylation of the synthetic peptide autocamtide-2. Reduction of extracellular Ca2+ levels (0.2 mM in treatment solution) or the addition of dl-2-amino-5-phosphonovaleric acid (APV) 25 microM blocked the low Mg2+-induced decrease in CaM kinase II-dependent substrate phosphorylation. Antagonists of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainic acid receptor or L-type voltage sensitive Ca2+ channel had no effect on the low Mg2+-induced decrease in CaM kinase II-dependent substrate phosphorylation. The results of this study demonstrate that the decrease in CaM kinase II activity associated with this model of epileptogenesis involves a selective Ca2+/NMDA receptor-dependent mechanism and may contribute to the production and maintenance of SREDs in this model." @default.
• W2143664312 created "2016-06-24" @default.
• W2143664312 creator A5017300374 @default.
• W2143664312 creator A5029277785 @default.
• W2143664312 creator A5055685108 @default.
• W2143664312 creator A5058303942 @default.
• W2143664312 date "2008-06-01" @default.
• W2143664312 modified "2023-09-26" @default.
• W2143664312 title "Epileptogenesis causes an N-methyl-d-aspartate receptor/Ca2+-dependent decrease in Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent epileptiform discharges" @default.
• W2143664312 cites W1530825321 @default.
• W2143664312 cites W1594117694 @default.
• W2143664312 cites W1659153222 @default.
• W2143664312 cites W1688836245 @default.
• W2143664312 cites W1700879768 @default.
• W2143664312 cites W1965013830 @default.
• W2143664312 cites W1967463041 @default.
• W2143664312 cites W1972649124 @default.
• W2143664312 cites W1979406476 @default.
• W2143664312 cites W1979912313 @default.
• W2143664312 cites W1982438414 @default.
• W2143664312 cites W1986245436 @default.
• W2143664312 cites W1990195443 @default.
• W2143664312 cites W1993940179 @default.
• W2143664312 cites W1994364049 @default.
• W2143664312 cites W1995322916 @default.
• W2143664312 cites W1996977555 @default.
• W2143664312 cites W1997045452 @default.
• W2143664312 cites W2002404202 @default.
• W2143664312 cites W2008520902 @default.
• W2143664312 cites W2021860558 @default.
• W2143664312 cites W2026700361 @default.
• W2143664312 cites W2038468284 @default.
• W2143664312 cites W2039508416 @default.
• W2143664312 cites W2042024865 @default.
• W2143664312 cites W2048561499 @default.
• W2143664312 cites W2051493425 @default.
• W2143664312 cites W2052322593 @default.
• W2143664312 cites W2054602879 @default.
• W2143664312 cites W2056741090 @default.
• W2143664312 cites W2057216398 @default.
• W2143664312 cites W2057809958 @default.
• W2143664312 cites W2059500628 @default.
• W2143664312 cites W2062051774 @default.
• W2143664312 cites W2066857662 @default.
• W2143664312 cites W2068027003 @default.
• W2143664312 cites W2073907958 @default.
• W2143664312 cites W2083865194 @default.
• W2143664312 cites W2088481798 @default.
• W2143664312 cites W2091649923 @default.
• W2143664312 cites W2093316965 @default.
• W2143664312 cites W2149845791 @default.
• W2143664312 cites W2167607970 @default.
• W2143664312 cites W2169375053 @default.
• W2143664312 cites W2273738402 @default.
• W2143664312 cites W2304512189 @default.
• W2143664312 doi "https://doi.org/10.1016/j.ejphar.2008.04.021" @default.
• W2143664312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2819419" @default.
• W2143664312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18495112" @default.
• W2143664312 hasPublicationYear "2008" @default.
• W2143664312 type Work @default.
• W2143664312 sameAs 2143664312 @default.
• W2143664312 citedByCount "25" @default.
• W2143664312 countsByYear W21436643122012 @default.
• W2143664312 countsByYear W21436643122013 @default.
• W2143664312 countsByYear W21436643122014 @default.
• W2143664312 countsByYear W21436643122015 @default.
• W2143664312 countsByYear W21436643122016 @default.
• W2143664312 countsByYear W21436643122017 @default.
• W2143664312 countsByYear W21436643122018 @default.
• W2143664312 countsByYear W21436643122019 @default.
• W2143664312 countsByYear W21436643122020 @default.
• W2143664312 countsByYear W21436643122021 @default.
• W2143664312 countsByYear W21436643122022 @default.
• W2143664312 crossrefType "journal-article" @default.
• W2143664312 hasAuthorship W2143664312A5017300374 @default.
• W2143664312 hasAuthorship W2143664312A5029277785 @default.
• W2143664312 hasAuthorship W2143664312A5055685108 @default.
• W2143664312 hasAuthorship W2143664312A5058303942 @default.
• W2143664312 hasBestOaLocation W21436643122 @default.
• W2143664312 hasConcept C148762608 @default.
• W2143664312 hasConcept C160268369 @default.
• W2143664312 hasConcept C169760540 @default.
• W2143664312 hasConcept C170493617 @default.
• W2143664312 hasConcept C181199279 @default.
• W2143664312 hasConcept C184235292 @default.
• W2143664312 hasConcept C185592680 @default.
• W2143664312 hasConcept C195794163 @default.
• W2143664312 hasConcept C2776108384 @default.
• W2143664312 hasConcept C29688787 @default.
• W2143664312 hasConcept C55493867 @default.
• W2143664312 hasConcept C57236427 @default.
• W2143664312 hasConcept C61174792 @default.
• W2143664312 hasConcept C67018056 @default.
• W2143664312 hasConcept C86803240 @default.
• W2143664312 hasConcept C95444343 @default.
• W2143664312 hasConcept C97029542 @default.
• W2143664312 hasConceptScore W2143664312C148762608 @default.
• W2143664312 hasConceptScore W2143664312C160268369 @default.

• next