Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143669794> ?p ?o ?g. }
- W2143669794 endingPage "101" @default.
- W2143669794 startingPage "92" @default.
- W2143669794 abstract "The metabolism of progesterone (PROG) by cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17α-hydroxyprogesterone (17-OHPROG) and 16α-hydroxyprogesterone (16-OHPROG) in humans. Unlike 17-OHPROG, 16-OHPROG is not metabolised further in steroidogenic tissue. While this metabolite can be readily detected in serum and urine, its physiological role remains unclear. This paper reviews the production of 16-OHPROG by human CYP17A1 by providing insight into the catalysis of PROG by CYP17A1 and highlights the role of Ala105 in the 16α-hydroxylation reaction. As 16-OHPROG has been putatively linked to reproductive function, we investigated the interaction of this steroid metabolite with both isoforms of the human progesterone receptor (hPR). We show for the first time that 16-OHPROG can bind to both hPR-A and hPR-B and act as an agonist for both receptors." @default.
- W2143669794 created "2016-06-24" @default.
- W2143669794 creator A5022369864 @default.
- W2143669794 creator A5033292249 @default.
- W2143669794 creator A5058540463 @default.
- W2143669794 creator A5061302629 @default.
- W2143669794 creator A5069314289 @default.
- W2143669794 creator A5070050962 @default.
- W2143669794 date "2011-04-01" @default.
- W2143669794 modified "2023-10-16" @default.
- W2143669794 title "16α-Hydroxyprogesterone: Origin, biosynthesis and receptor interaction" @default.
- W2143669794 cites W1498652161 @default.
- W2143669794 cites W1533372435 @default.
- W2143669794 cites W1544677256 @default.
- W2143669794 cites W1557985051 @default.
- W2143669794 cites W1570978364 @default.
- W2143669794 cites W1598886839 @default.
- W2143669794 cites W1601227551 @default.
- W2143669794 cites W1963932941 @default.
- W2143669794 cites W1964185479 @default.
- W2143669794 cites W1966176758 @default.
- W2143669794 cites W1966533731 @default.
- W2143669794 cites W1972891003 @default.
- W2143669794 cites W1972931629 @default.
- W2143669794 cites W1974791065 @default.
- W2143669794 cites W1975647499 @default.
- W2143669794 cites W1978746381 @default.
- W2143669794 cites W1979442991 @default.
- W2143669794 cites W1980898029 @default.
- W2143669794 cites W1981718840 @default.
- W2143669794 cites W1982557387 @default.
- W2143669794 cites W1986232120 @default.
- W2143669794 cites W1986549090 @default.
- W2143669794 cites W1987417875 @default.
- W2143669794 cites W1992115897 @default.
- W2143669794 cites W1993610997 @default.
- W2143669794 cites W1996000829 @default.
- W2143669794 cites W1999419842 @default.
- W2143669794 cites W2001540073 @default.
- W2143669794 cites W2005757009 @default.
- W2143669794 cites W2006602404 @default.
- W2143669794 cites W2010143253 @default.
- W2143669794 cites W2021231181 @default.
- W2143669794 cites W2028695869 @default.
- W2143669794 cites W2030089759 @default.
- W2143669794 cites W2031340722 @default.
- W2143669794 cites W2031512686 @default.
- W2143669794 cites W2036268251 @default.
- W2143669794 cites W2036556150 @default.
- W2143669794 cites W2040877330 @default.
- W2143669794 cites W2044056900 @default.
- W2143669794 cites W2047177188 @default.
- W2143669794 cites W2047968184 @default.
- W2143669794 cites W2049718726 @default.
- W2143669794 cites W2051175552 @default.
- W2143669794 cites W2054613778 @default.
- W2143669794 cites W2054853354 @default.
- W2143669794 cites W2056357500 @default.
- W2143669794 cites W2056533698 @default.
- W2143669794 cites W2059850722 @default.
- W2143669794 cites W2063125096 @default.
- W2143669794 cites W2064969010 @default.
- W2143669794 cites W2066866556 @default.
- W2143669794 cites W2068078932 @default.
- W2143669794 cites W2068195892 @default.
- W2143669794 cites W2068708003 @default.
- W2143669794 cites W2071793355 @default.
- W2143669794 cites W2075080834 @default.
- W2143669794 cites W2076807578 @default.
- W2143669794 cites W2078510487 @default.
- W2143669794 cites W2089318261 @default.
- W2143669794 cites W2092198518 @default.
- W2143669794 cites W2110661248 @default.
- W2143669794 cites W2115296460 @default.
- W2143669794 cites W2117606202 @default.
- W2143669794 cites W2118815152 @default.
- W2143669794 cites W2119543553 @default.
- W2143669794 cites W2119830096 @default.
- W2143669794 cites W2124770698 @default.
- W2143669794 cites W2125670057 @default.
- W2143669794 cites W2126119140 @default.
- W2143669794 cites W2126733133 @default.
- W2143669794 cites W2130766475 @default.
- W2143669794 cites W2142886860 @default.
- W2143669794 cites W2148734624 @default.
- W2143669794 cites W2152874499 @default.
- W2143669794 cites W2165209019 @default.
- W2143669794 cites W2165603655 @default.
- W2143669794 cites W2165755939 @default.
- W2143669794 cites W2462164535 @default.
- W2143669794 cites W2468334622 @default.
- W2143669794 cites W3028163558 @default.
- W2143669794 cites W4322698285 @default.
- W2143669794 cites W4322702785 @default.
- W2143669794 doi "https://doi.org/10.1016/j.mce.2010.11.016" @default.
- W2143669794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21095220" @default.
- W2143669794 hasPublicationYear "2011" @default.
- W2143669794 type Work @default.