Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143669946> ?p ?o ?g. }
- W2143669946 endingPage "126" @default.
- W2143669946 startingPage "117" @default.
- W2143669946 abstract "The stress-activated protein kinase p38 and nitric oxide (NO) are proposed downstream effectors of excitotoxic cell death. Although the postsynaptic density protein PSD95 can recruit the calcium-dependent neuronal NO synthase (nNOS) to the mouth of the calcium-permeable NMDA receptor, and depletion of PSD95 inhibits excitotoxicity, the possibility that selective uncoupling of nNOS from PSD95 might be neuroprotective is unexplored. The relationship between excitotoxic stress-generated NO and activation of p38, and the significance of the PSD95-nNOS interaction to p38 activation also remain unclear. We find that NOS inhibitors reduce both glutamate-induced p38 activation and the resulting neuronal death, whereas NO donor has effects consistent with NO as an upstream regulator of p38 in glutamate-induced cell death. Experiments using a panel of decoy constructs targeting the PSD95-nNOS interaction suggest that this interaction and subsequent NO production are critical for glutamate-induced p38 activation and the ensuing cell death, and demonstrate that the PSD95-nNOS interface provides a genuine possibility for design of neuroprotective drugs with increased selectivity." @default.
- W2143669946 created "2016-06-24" @default.
- W2143669946 creator A5007644222 @default.
- W2143669946 creator A5017323068 @default.
- W2143669946 creator A5034579096 @default.
- W2143669946 creator A5049640837 @default.
- W2143669946 creator A5081400503 @default.
- W2143669946 creator A5083616493 @default.
- W2143669946 date "2005-01-03" @default.
- W2143669946 modified "2023-10-14" @default.
- W2143669946 title "The PSD95–nNOS interface" @default.
- W2143669946 cites W1500368251 @default.
- W2143669946 cites W1532490237 @default.
- W2143669946 cites W1653383134 @default.
- W2143669946 cites W1751748906 @default.
- W2143669946 cites W1816379352 @default.
- W2143669946 cites W1926494419 @default.
- W2143669946 cites W1966434770 @default.
- W2143669946 cites W1966928113 @default.
- W2143669946 cites W1967117930 @default.
- W2143669946 cites W1974706357 @default.
- W2143669946 cites W1977394169 @default.
- W2143669946 cites W1993385893 @default.
- W2143669946 cites W1994771592 @default.
- W2143669946 cites W2000798119 @default.
- W2143669946 cites W2002287054 @default.
- W2143669946 cites W2010789010 @default.
- W2143669946 cites W2018877420 @default.
- W2143669946 cites W2021959699 @default.
- W2143669946 cites W2036839645 @default.
- W2143669946 cites W2039210066 @default.
- W2143669946 cites W2045246673 @default.
- W2143669946 cites W2050974084 @default.
- W2143669946 cites W2063541383 @default.
- W2143669946 cites W2066581734 @default.
- W2143669946 cites W2066963022 @default.
- W2143669946 cites W2067113295 @default.
- W2143669946 cites W2070851832 @default.
- W2143669946 cites W2071560641 @default.
- W2143669946 cites W2071577536 @default.
- W2143669946 cites W2073730363 @default.
- W2143669946 cites W2074187719 @default.
- W2143669946 cites W2079787007 @default.
- W2143669946 cites W2087733046 @default.
- W2143669946 cites W2090561125 @default.
- W2143669946 cites W2110898773 @default.
- W2143669946 cites W2115153703 @default.
- W2143669946 cites W2118392131 @default.
- W2143669946 cites W2128994713 @default.
- W2143669946 cites W2143399447 @default.
- W2143669946 cites W2146424916 @default.
- W2143669946 cites W2152464685 @default.
- W2143669946 cites W2152549690 @default.
- W2143669946 cites W2160038308 @default.
- W2143669946 cites W2162611266 @default.
- W2143669946 cites W2738996050 @default.
- W2143669946 cites W4234401654 @default.
- W2143669946 doi "https://doi.org/10.1083/jcb.200407024" @default.
- W2143669946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2171658" @default.
- W2143669946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15631993" @default.
- W2143669946 hasPublicationYear "2005" @default.
- W2143669946 type Work @default.
- W2143669946 sameAs 2143669946 @default.
- W2143669946 citedByCount "132" @default.
- W2143669946 countsByYear W21436699462012 @default.
- W2143669946 countsByYear W21436699462013 @default.
- W2143669946 countsByYear W21436699462014 @default.
- W2143669946 countsByYear W21436699462015 @default.
- W2143669946 countsByYear W21436699462016 @default.
- W2143669946 countsByYear W21436699462017 @default.
- W2143669946 countsByYear W21436699462018 @default.
- W2143669946 countsByYear W21436699462020 @default.
- W2143669946 countsByYear W21436699462021 @default.
- W2143669946 countsByYear W21436699462022 @default.
- W2143669946 countsByYear W21436699462023 @default.
- W2143669946 crossrefType "journal-article" @default.
- W2143669946 hasAuthorship W2143669946A5007644222 @default.
- W2143669946 hasAuthorship W2143669946A5017323068 @default.
- W2143669946 hasAuthorship W2143669946A5034579096 @default.
- W2143669946 hasAuthorship W2143669946A5049640837 @default.
- W2143669946 hasAuthorship W2143669946A5081400503 @default.
- W2143669946 hasAuthorship W2143669946A5083616493 @default.
- W2143669946 hasBestOaLocation W21436699461 @default.
- W2143669946 hasConcept C12554922 @default.
- W2143669946 hasConcept C169760540 @default.
- W2143669946 hasConcept C170493617 @default.
- W2143669946 hasConcept C184235292 @default.
- W2143669946 hasConcept C187541742 @default.
- W2143669946 hasConcept C190283241 @default.
- W2143669946 hasConcept C25498285 @default.
- W2143669946 hasConcept C2781012912 @default.
- W2143669946 hasConcept C31573885 @default.
- W2143669946 hasConcept C51551487 @default.
- W2143669946 hasConcept C55493867 @default.
- W2143669946 hasConcept C61174792 @default.
- W2143669946 hasConcept C67018056 @default.
- W2143669946 hasConcept C86803240 @default.
- W2143669946 hasConcept C95444343 @default.