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- W2143670169 abstract "The stem cells (SCs) of the corneal epithelium located in the limbal basal layer are the ultimate source to maintain corneal epithelial homeostasis. Like other adult tissue-specific SCs, self renewal and fate decision of limbal SCs are regulated by a specialized in vivo microenvironment, termed niche. Loss of limbal SCs or dysfunction of the limbal niche renders corneas with a unique clinical disease labeled limbal stem cell deficiency (LSCD). Besides transplantation of autologous or allogeneic limbal SCs or amniotic membrane, a new strategy of treating LSCD is to transplant a bio-engineered graft by expanding limbal SCs ex vivo. Herein, we conduct a critical appraisal of six protocols that have successfully been practiced in treating human patients with LSCD, and identify issues whether niche regulation has been disrupted or maintained during isolation and expansion. Consequently, we propose a future direction that may circumvent the potential pitfalls existing in these conventional protocols by preserving the interaction between limbal SCs and their native niche cells during isolation and expansion. Such an approach may one day help realize considerable promise held by adult SCs in treating a number of diseases." @default.
- W2143670169 created "2016-06-24" @default.
- W2143670169 creator A5006881601 @default.
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- W2143670169 creator A5015069162 @default.
- W2143670169 creator A5032718030 @default.
- W2143670169 creator A5035358583 @default.
- W2143670169 date "2010-12-01" @default.
- W2143670169 modified "2023-10-04" @default.
- W2143670169 title "Critical Appraisal of Ex Vivo Expansion of Human Limbal Epithelial Stem Cells" @default.
- W2143670169 cites W108491111 @default.
- W2143670169 cites W120067713 @default.
- W2143670169 cites W140821665 @default.
- W2143670169 cites W1483167997 @default.
- W2143670169 cites W1483925966 @default.
- W2143670169 cites W1494685416 @default.
- W2143670169 cites W1505671001 @default.
- W2143670169 cites W1541538097 @default.
- W2143670169 cites W1548920799 @default.
- W2143670169 cites W1553509509 @default.
- W2143670169 cites W163285829 @default.
- W2143670169 cites W167208729 @default.
- W2143670169 cites W1964228231 @default.
- W2143670169 cites W1965169674 @default.
- W2143670169 cites W1967479683 @default.
- W2143670169 cites W1968663547 @default.
- W2143670169 cites W1969133801 @default.
- W2143670169 cites W1970291858 @default.
- W2143670169 cites W1972609931 @default.
- W2143670169 cites W1973256561 @default.
- W2143670169 cites W1976451037 @default.
- W2143670169 cites W1976966028 @default.
- W2143670169 cites W1977091888 @default.
- W2143670169 cites W1977154080 @default.
- W2143670169 cites W1979623069 @default.
- W2143670169 cites W1980123068 @default.
- W2143670169 cites W1980332250 @default.
- W2143670169 cites W1982347881 @default.
- W2143670169 cites W1984187020 @default.
- W2143670169 cites W1987612449 @default.
- W2143670169 cites W1995177850 @default.
- W2143670169 cites W1995865777 @default.
- W2143670169 cites W2002131773 @default.
- W2143670169 cites W2002935341 @default.
- W2143670169 cites W2003566504 @default.
- W2143670169 cites W2022582986 @default.
- W2143670169 cites W2023468388 @default.
- W2143670169 cites W2024286953 @default.
- W2143670169 cites W2036607348 @default.
- W2143670169 cites W2037477217 @default.
- W2143670169 cites W2039157833 @default.
- W2143670169 cites W2043541388 @default.
- W2143670169 cites W2044405591 @default.
- W2143670169 cites W2048638072 @default.
- W2143670169 cites W2048721112 @default.
- W2143670169 cites W2048799419 @default.
- W2143670169 cites W2048957342 @default.
- W2143670169 cites W2049043712 @default.
- W2143670169 cites W205055112 @default.
- W2143670169 cites W2052354463 @default.
- W2143670169 cites W2052590714 @default.
- W2143670169 cites W2054592169 @default.
- W2143670169 cites W2056598800 @default.
- W2143670169 cites W2057364537 @default.
- W2143670169 cites W2057514048 @default.
- W2143670169 cites W2063639875 @default.
- W2143670169 cites W2068190122 @default.
- W2143670169 cites W2071110385 @default.
- W2143670169 cites W2071196172 @default.
- W2143670169 cites W2071595764 @default.
- W2143670169 cites W2072332014 @default.
- W2143670169 cites W2072676174 @default.
- W2143670169 cites W2073644280 @default.
- W2143670169 cites W2075024160 @default.
- W2143670169 cites W2076664336 @default.
- W2143670169 cites W2077631683 @default.
- W2143670169 cites W2078393347 @default.
- W2143670169 cites W2080986389 @default.
- W2143670169 cites W2091580452 @default.
- W2143670169 cites W2094008821 @default.
- W2143670169 cites W2096604029 @default.
- W2143670169 cites W2097304851 @default.
- W2143670169 cites W2119226652 @default.
- W2143670169 cites W2120327297 @default.
- W2143670169 cites W2121062346 @default.
- W2143670169 cites W2126917358 @default.
- W2143670169 cites W2128078747 @default.
- W2143670169 cites W2128284635 @default.
- W2143670169 cites W2132984034 @default.
- W2143670169 cites W2137956382 @default.
- W2143670169 cites W2138058263 @default.
- W2143670169 cites W2148308138 @default.
- W2143670169 cites W2150042936 @default.
- W2143670169 cites W2151581622 @default.
- W2143670169 cites W2161785869 @default.
- W2143670169 cites W2168211018 @default.
- W2143670169 cites W2168291956 @default.
- W2143670169 cites W2335673299 @default.