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• W2143670394 abstract "Farnesol (FOH) and geranylgeraniol (GGOH) possess anti-tumor potential, while peroxisome proliferator-activated receptor γ (PPARγ) has exhibited modulating effects in colorectal cancers. We investigated the anti-carcinogenic effects of these isoprenols in HT-29 and HCT116 colon cancer cells and PPARγ involvement. Results indicate that the FOH- and GGOH-induced apoptosis involve caspase 3 activation, PARP cleavage, nuclear chromatin condensation, down-regulation of Bcl-xL and survivin expression, with increased PPARγ promoter activity. Pretreatment of the PPARγ antagonist GW9662 reduces FOH-induced growth inhibition and the associated PARP cleavage. We conclude that PPARγ activation is essential to elicit the anti-carcinogenic action of herbal isoprenols in colonic cancer cells." @default.
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• W2143670394 date "2008-01-01" @default.
• W2143670394 modified "2023-10-09" @default.
• W2143670394 title "Herbal Isoprenols Induce Apoptosis in Human Colon Cancer Cells Through Transcriptional Activation of PPARγ" @default.
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• W2143670394 doi "https://doi.org/10.1080/07357900801898656" @default.
• W2143670394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18608213" @default.
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