FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143707822> ?p ?o ?g. }

• W2143707822 endingPage "564" @default.
• W2143707822 startingPage "558" @default.
• W2143707822 abstract "Microtubules are among the most successful targets for development of compounds useful for anticancer therapy. Continuing our project to develop new small molecule antitumor agents, two new series of derivatives based on the 2-aroyl-4-phenylbenzofuran molecular skeleton were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle effects. SAR were elucidated with various substitutions on the benzoyl moiety at the 2-position of the benzofuran ring. The most promising compound in this series, the (5-hydroxy-4-phenylbenzofuran-2-yl)(4-methoxyphenyl)methanone derivative (3d), has significant growth inhibitory activity in the submicromolar range against the Molt4, CEM and HeLa cancer cell lines and interacts with tubulin by binding to the colchicine site. Exposure to 3d led to the arrest of K562 cells in the G2-M phase of the cell cycle and to the induction of apoptosis." @default.
• W2143707822 created "2016-06-24" @default.
• W2143707822 creator A5009366677 @default.
• W2143707822 creator A5020353004 @default.
• W2143707822 creator A5036528092 @default.
• W2143707822 creator A5038319371 @default.
• W2143707822 creator A5041567500 @default.
• W2143707822 creator A5058385092 @default.
• W2143707822 creator A5063804577 @default.
• W2143707822 creator A5070625007 @default.
• W2143707822 creator A5088149477 @default.
• W2143707822 creator A5088496504 @default.
• W2143707822 date "2008-11-01" @default.
• W2143707822 modified "2023-10-18" @default.
• W2143707822 title "Synthesis and Biological Evaluation of 2-aroyl-4-phenyl-5- hydroxybenzofurans as a New Class of Antitubulin Agents" @default.
• W2143707822 cites W1969615301 @default.
• W2143707822 cites W1983152359 @default.
• W2143707822 cites W1994297035 @default.
• W2143707822 cites W2016969487 @default.
• W2143707822 cites W2023070630 @default.
• W2143707822 cites W2048312098 @default.
• W2143707822 cites W2106521963 @default.
• W2143707822 cites W2174380832 @default.
• W2143707822 cites W2178278509 @default.
• W2143707822 cites W2179030167 @default.
• W2143707822 cites W2224757179 @default.
• W2143707822 cites W2414615250 @default.
• W2143707822 cites W2951244591 @default.
• W2143707822 doi "https://doi.org/10.2174/157340608786242007" @default.
• W2143707822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2731474" @default.
• W2143707822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18991740" @default.
• W2143707822 hasPublicationYear "2008" @default.
• W2143707822 type Work @default.
• W2143707822 sameAs 2143707822 @default.
• W2143707822 citedByCount "16" @default.
• W2143707822 countsByYear W21437078222015 @default.
• W2143707822 countsByYear W21437078222016 @default.
• W2143707822 countsByYear W21437078222017 @default.
• W2143707822 countsByYear W21437078222018 @default.
• W2143707822 countsByYear W21437078222019 @default.
• W2143707822 countsByYear W21437078222020 @default.
• W2143707822 countsByYear W21437078222021 @default.
• W2143707822 countsByYear W21437078222022 @default.
• W2143707822 crossrefType "journal-article" @default.
• W2143707822 hasAuthorship W2143707822A5009366677 @default.
• W2143707822 hasAuthorship W2143707822A5020353004 @default.
• W2143707822 hasAuthorship W2143707822A5036528092 @default.
• W2143707822 hasAuthorship W2143707822A5038319371 @default.
• W2143707822 hasAuthorship W2143707822A5041567500 @default.
• W2143707822 hasAuthorship W2143707822A5058385092 @default.
• W2143707822 hasAuthorship W2143707822A5063804577 @default.
• W2143707822 hasAuthorship W2143707822A5070625007 @default.
• W2143707822 hasAuthorship W2143707822A5088149477 @default.
• W2143707822 hasAuthorship W2143707822A5088496504 @default.
• W2143707822 hasBestOaLocation W21437078222 @default.
• W2143707822 hasConcept C105696609 @default.
• W2143707822 hasConcept C1491633281 @default.
• W2143707822 hasConcept C185592680 @default.
• W2143707822 hasConcept C190283241 @default.
• W2143707822 hasConcept C20418707 @default.
• W2143707822 hasConcept C21951064 @default.
• W2143707822 hasConcept C2776568683 @default.
• W2143707822 hasConcept C2776636253 @default.
• W2143707822 hasConcept C2777366897 @default.
• W2143707822 hasConcept C29537977 @default.
• W2143707822 hasConcept C54355233 @default.
• W2143707822 hasConcept C55493867 @default.
• W2143707822 hasConcept C62112901 @default.
• W2143707822 hasConcept C71240020 @default.
• W2143707822 hasConcept C84425145 @default.
• W2143707822 hasConcept C86803240 @default.
• W2143707822 hasConcept C95444343 @default.
• W2143707822 hasConceptScore W2143707822C105696609 @default.
• W2143707822 hasConceptScore W2143707822C1491633281 @default.
• W2143707822 hasConceptScore W2143707822C185592680 @default.
• W2143707822 hasConceptScore W2143707822C190283241 @default.
• W2143707822 hasConceptScore W2143707822C20418707 @default.
• W2143707822 hasConceptScore W2143707822C21951064 @default.
• W2143707822 hasConceptScore W2143707822C2776568683 @default.
• W2143707822 hasConceptScore W2143707822C2776636253 @default.
• W2143707822 hasConceptScore W2143707822C2777366897 @default.
• W2143707822 hasConceptScore W2143707822C29537977 @default.
• W2143707822 hasConceptScore W2143707822C54355233 @default.
• W2143707822 hasConceptScore W2143707822C55493867 @default.
• W2143707822 hasConceptScore W2143707822C62112901 @default.
• W2143707822 hasConceptScore W2143707822C71240020 @default.
• W2143707822 hasConceptScore W2143707822C84425145 @default.
• W2143707822 hasConceptScore W2143707822C86803240 @default.
• W2143707822 hasConceptScore W2143707822C95444343 @default.
• W2143707822 hasIssue "6" @default.
• W2143707822 hasLocation W21437078221 @default.
• W2143707822 hasLocation W21437078222 @default.
• W2143707822 hasLocation W21437078223 @default.
• W2143707822 hasLocation W21437078224 @default.
• W2143707822 hasOpenAccess W2143707822 @default.
• W2143707822 hasPrimaryLocation W21437078221 @default.
• W2143707822 hasRelatedWork W2350294409 @default.
• W2143707822 hasRelatedWork W2354294515 @default.

• next